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4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase

This is an abbreviated version!
For detailed information about 4a-hydroxytetrahydrobiopterin dehydratase, go to the full flat file.

Word Map on EC 4.2.1.96

Reaction

4a-hydroxytetrahydrobiopterin
=
6,7-dihydrobiopterin
 +
H2O

Synonyms

4 alpha-Hydroxy-tetrahydropterin dehydratase, 4-alpha-hydroxy-tetrahydropterin dehydratase, 4-alpha-hydroxytetrahydrobiopterin dehydratase, 4a-Carbinolamine dehydratase, 4a-Hydroxytetrahydrobiopterin dehydratase, 4a-Hydroxytetrahydropterin dehydratase, carbinolamine-4a-dehydratase, cDcoH, DCoH, DCoH/PCD, DcoH2, DCoHalpha, Dehydratase, 4a-carbinolamine, Dimerization cofactor of hepatocyte nuclear factor 1-alpha, Dimerization cofactor of HNF1, Dimerization factor of HNF1/pterin-4alpha-carbinolamine dehydratase, GenBank AE000671-derived protein GI 2982796, More, P4aCD, PCD, PCD/DCoH, PCD/PhhB, PCDH, Phenylalanine hydroxylase-stimulating protein, Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase, PhhB, PHS, PHS/PCD, pterin 4a-carbinolamine dehydratase, Pterin carbinolamine dehydratase, Pterin-4 alpha-carbinolamine dehydratase, Pterin-4-alpha-carbinolamine dehydratase, Pterin-4a-carbinolamine dehydratase, Pterin-4a-carbinolamine dehydratase (Aquifex aeolicus gene phhB), Pterin-4a-carbinolamine dehydratase/dimerization cofactor of HNF1, Pterin-4alpha-carbinolamine dehydratase, Pterin-4alpha-carbinolamine dehydratase (PCD)/dimerization cofactor for the transcription factor HBF-1alpha, XDCoH

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase

Reference

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Reference on EC 4.2.1.96 - 4a-hydroxytetrahydrobiopterin dehydratase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hauer, C.R.; Rebrin, I.; Thoeny, B.; Neuheiser, F.; Curtius, H.C.; Hunziker, P.; Blau, N.; Ghisla, S.; Heizmann, C.W.
Phenylalanine hydoxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver
J. Biol. Chem.
268
4828-4831
1993
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Rebrin, I.; Bailey, S.W.; Ayling, J.E.
Activity of the bifunctional protein 4alpha-hydroxy-tetrahydropterin dehydratase/DCOH during human fetal development: correlation with dihydropteridine reductase activity and tetrahydrobiopterin levels
Biochem. Biophys. Res. Commun.
217
958-965
1995
Homo sapiens
Manually annotated by BRENDA team
Curtius, H.C.; Ghisla, S.; Hasegawa, H.; Blau, N.; Rebrin, I.
Progress in the study of biosynthesis and role of 7-substituted pterins: function of pterin-4a-carbinolamine dehydratase
Adv. Exp. Med. Biol.
338
107-110
1993
Homo sapiens
Manually annotated by BRENDA team
Thoeny, B.; Neuheiser, F.; Blau, N.; Heizmann, C.W.
Characterization of the human PCBD gene encoding the bifunctional protein pterin-4alpha-carbinolamine dehydratase/dimerization cofactor for the transcription factor HNF-1alpha
Biochem. Biophys. Res. Commun.
210
966-973
1995
Homo sapiens
Manually annotated by BRENDA team
Köster, S.; Stier, G.; Kubasch, N.; Curtius, H.C.; Ghisla, S.
Pterin-4alpha-carbinolamine dehydratase from Pseudomonas aeruginosa: characterization, catalytic mechanism and comparison to the human enzyme
Biol. Chem.
379
1427-1432
1998
Homo sapiens, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Rebrin, I.; Petruschka, L.; Curtius, H.Ch.; Adler, C.; Herrmann, F.H.
Human liver pterin 4alpha-carbinolamine dehydratase. Purification and characterization
Pteridines
3
55-57
1992
Homo sapiens
-
Manually annotated by BRENDA team
Ficner, R.; Sauer, U.H.; Stier, G.; Suck, D.
Three-dimensional structure of the bifunctional protein PCH/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1
EMBO J.
14
2034-2042
1995
Rattus norvegicus
Manually annotated by BRENDA team
Koester, S.; Thoeny, B.; Macheroux, P.; Curtius, H.C.; Heizmann, C.W.; Pfleiderer, W.; Ghisla, S.
Human pterin-4alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1alpha
Eur. J. Biochem.
231
414-423
1995
Homo sapiens
Manually annotated by BRENDA team
Köster, S.; Stier, G.; Ficner, R.; Hoezer, M.; Curtius, H.C.; Suck, D.; Ghisla, S.
Location of the active site and proposed catalytic mechanism of pterin-4alpha-carbinolamine dehydratase
Eur. J. Biochem.
241
858-864
1996
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Davis, M.D.; Kaufman, S.; Milstien, S.
Distribution of 4a-hydroxytetrahydropterin dehydratase in rat tissues
FEBS Lett.
302
73-76
1992
Rattus norvegicus
Manually annotated by BRENDA team
Ficner, R.; Sauer, U.H.; Ceska, T.A.; Stier, G.; Suck, D.
Crystallization and preliminary crystallographic studies of recombinant dimerization cofactor of transcription factor HNF1/pterin-4alpha-carbinolamine dehydratase from liver
FEBS Lett.
357
62-64
1995
Rattus norvegicus
Manually annotated by BRENDA team
Johen, G.; Kowlessur, D.; Citron, B.A.; Kaufman, S.
Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occuring mutants associated with hyperphenylalaninemia
Proc. Natl. Acad. Sci. USA
92
12384-12388
1995
Homo sapiens
Manually annotated by BRENDA team
Citron, B.A.; Davis, M.D.; Milstien, S.; Gutierrez, J.; Mendel, D.B.; Crabtree, G.R.; Kaufman, S.
Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins
Proc. Natl. Acad. Sci. USA
89
11891-11894
1992
Homo sapiens
Manually annotated by BRENDA team
Rebrin, I.; Bailey, S.W.; Boerth, S.R.; Ardell, M.D.; Ayling, J.E.
Catalytic characterization of 4alpha-hydroxytetrahydropterin dehydratase
Biochemistry
34
5801-5810
1995
Rattus norvegicus
Manually annotated by BRENDA team
Kim, J.L.; Burley, S.K.; Hughes, H.
PCH/DCoH: more than a second molecular saddle
Curr. Biol.
3
531-534
1995
Rattus norvegicus
Manually annotated by BRENDA team
Rebrin, I.; Thoeny, B.; Bailey, S.W.; Ayling, J.E.
Stereospecificity and catalytic function of histidine residues in 4alpha-hydroxy-tetrahydropterin dehydratase/DCoH
Biochemistry
37
11246-11254
1998
Rattus norvegicus (P61459)
Manually annotated by BRENDA team
Connolly, E.; Donlon, J.
Effects of dietary glycerol on the expression of pterin carbinolamine dehydratase in the rat
Biochem. J.
373
993-997
2003
Rattus norvegicus
Manually annotated by BRENDA team
Rose, R.B.; Pullen, K.E.; Bayle, J.H.; Crabtree, G.R.; Alber, T.
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
Biochemistry
43
7345-7355
2004
Mus musculus (Q9CZL5)
Manually annotated by BRENDA team
Song, J.; Xia, T.; Jensen, R.A.
PhhB, a Pseudomonas aeruginosa homolog of mammalian pterin 4alpha-carbinolamine dehydratase/DCoH, does not regulate expression of phenylalanine hydroxylase at the transcriptional level
J. Bacteriol.
181
2789-2796
1999
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
Manually annotated by BRENDA team
Hevel, J.M.; Stewart, J.A.; Gross, K.L.; Ayling, J.E.
Can the DCoHalpha isozyme compensate in patients with 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH deficiency?
Mol. Genet. Metab.
88
38-46
2006
Homo sapiens
Manually annotated by BRENDA team
Hevel, J.M.; Pande, P.; Viera-Oveson, S.; Sudweeks, T.J.; Jaffree, L.S.; Hansen, C.M.; Ayling, J.E.
Determinants of oligomerization of the bifunctional protein DCoHalpha and the effect on its enzymatic and transcriptional coactivator activities
Arch. Biochem. Biophys.
477
356-362
2008
Homo sapiens (Q9H0N5)
Manually annotated by BRENDA team
Cameron, S.; Fyffe, S.A.; Goldie, S.; Hunter, W.N.
Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues
Mol. Biochem. Parasitol.
158
131-138
2008
Toxoplasma gondii (Q2Q449), Toxoplasma gondii
Manually annotated by BRENDA team
Pribat, A.; Blaby, I.K.; Lara-Nunez, A.; Gregory, J.F.; de Crecy-Lagard, V.; Hanson, A.D.
FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa
J. Bacteriol.
192
475-482
2010
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Longo, N.
Disorders of biopterin metabolism
J. Inherit. Metab. Dis.
32
333-342
2009
Homo sapiens
Manually annotated by BRENDA team
Rho, H.; Jones, C.N.; Rose, R.B.
Kinetic stability may determine the interaction dynamics of the bifunctional protein DCoH1, the dimerization cofactor of the transcription factor HNF-1alpha
Biochemistry
49
10187-10197
2010
Rattus norvegicus
Manually annotated by BRENDA team
Pribat, A.; Noiriel, A.; Morse, A.M.; Davis, J.M.; Fouquet, R.; Loizeau, K.; Ravanel, S.; Frank, W.; Haas, R.; Reski, R.; Bedair, M.; Sumner, L.W.; Hanson, A.D.
Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts
Plant Cell
22
3410-3422
2010
Physcomitrium patens, Pinus taeda
Manually annotated by BRENDA team
Hara, R.; Kino, K.
Enhanced synthesis of 5-hydroxy-L-tryptophan through tetrahydropterin regeneration
AMB Express
3
70
2013
Pseudomonas syringae (Q48G05)
Manually annotated by BRENDA team
Li, W.; Gong, M.; Shu, R.; Li, X.; Gao, J.; Meng, Y.
Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori
Comp. Biochem. Physiol. B
186
20-27
2015
Bombyx mori
Manually annotated by BRENDA team
Feiz, L.; Williams-Carrier, R.; Belcher, S.; Montano, M.; Barkan, A.; Stern, D.B.
A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants
Plant J.
80
862-869
2014
Zea mays (B6TSX9), Zea mays
Manually annotated by BRENDA team