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4.2.1.94: scytalone dehydratase

This is an abbreviated version!
For detailed information about scytalone dehydratase, go to the full flat file.

Word Map on EC 4.2.1.94

Reaction

Scytalone
=
1,3,8-Trihydroxynaphthalene
 +
H2O

Synonyms

dehydratase, scytalone, Sal1, SCD, SCD1, scytalone dehydratase1, SS1G_13314

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.94 scytalone dehydratase

Reference

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Reference on EC 4.2.1.94 - scytalone dehydratase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wheeler, M.H.; Greenblatt, G.A.
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease
Exp. Mycol.
12
151-160
1988
Pyricularia oryzae
-
Manually annotated by BRENDA team
Tajima, S.; Kubo, Y.; Furusawa, I.; Shishiyama, J.
Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus
Exp. Mycol.
13
69-76
1989
Bipolaris oryzae
-
Manually annotated by BRENDA team
Butler, M.J.; Lazarovits, G.; Higgins, V.J.; Lachance, M.A.
Partial purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp. and other fungi
Exp. Mycol.
12
367-376
1988
Alternaria solani, Cladosporium cucumerinum, no activity in yeast extracts that do not form pentaketide melanins, Phaeococcomyces sp., Verticillium albo-atrum, Verticillium dahliae
-
Manually annotated by BRENDA team
Lundqvist, T.; Weber, P.C.; Hodge, C.N.; Braswell, E.H.; Rice, J.; Pierce, J.
Preliminary crystallographic studies on scytalone dehydratase from Magnaporthe grisea
J. Mol. Biol.
232
999-1002
1993
Pyricularia grisea
Manually annotated by BRENDA team
Lundqvist, T.; Rice, J.; Hodge, C.N.; Basarab, G.S.; Pierce, J.; Lindqvist, Y.
Crystal structure of scytalone dehydratase - a disease determinant of the rice pathogen, Magnaporthe grisea
Structure
2
937-944
1994
Pyricularia grisea
Manually annotated by BRENDA team
Basarab, G.S.; Steffens, J.J.; Wawrzak, Z.; Schwartz, R.S.; Lundqvist, T.; Jordan, D.B.
Catalytic mechanism of scytalone dehydratase: site-directed mutagenisis, kinetic isotope effects, and alternate substrates
Biochemistry
38
6012-6024
1999
Pyricularia grisea
Manually annotated by BRENDA team
Zheng, Y.J.; Bruice, T.C.
Role of a critical water in scytalone dehydratase-catalyzed reaction
Proc. Natl. Acad. Sci. USA
95
4158-4163
1998
Pyricularia grisea
Manually annotated by BRENDA team
Jordan, D.B.; Zheng, Y.J.; Lockett, B.A.; Basarab, G.S.
Stereochemistry of the enolization of scytalone by scytalone dehydratase
Biochemistry
39
2276-2282
2000
Pyricularia grisea
Manually annotated by BRENDA team
Jordan, D.B.; Basarab, G.S.; Steffens, J.J.; Schwartz, R.S.; Doughty, J.G.
Tight binding inhibitors of scytalone dehydratase: effects of site-directed mutations
Biochemistry
39
8593-8602
2000
Pyricularia grisea
Manually annotated by BRENDA team
Zheng, Y.J.; Basarab, G.S.; Jordan, D.B.
Roles of substrate distortion and intramolecular hydrogen bonding in enzymatic catalysis by scytalone dehydratase
Biochemistry
41
820-826
2002
Pyricularia grisea
Manually annotated by BRENDA team
Motoyama, T.; Nakasako, M.; Yamaguchi, I.
Crystallization of scytalone dehydratase F162A mutant in the unligated state and a preliminary X-ray diffraction study at 37 K
Acta Crystallogr. Sect. D
58
148-150
2002
Pyricularia oryzae
Manually annotated by BRENDA team
Nakasako, M.; Motoyama, T.; Kurahashi, Y.; Yamaguchi, I.
Cryogenic X-ray crystal structure analysis for the complex of scytalone dehydratase of a rice blast fungus and its tight-binding inhibitor, carpropamid: the structural basis of tight-binding inhibition
Biochemistry
37
9931-9939
1998
Pyricularia oryzae (P56221), Pyricularia oryzae
Manually annotated by BRENDA team
Wawrzak, Z.; Sandalova, T.; Steffens, J.J.; Basarab, G.S.; Lundqvist, T.; Lindqvist, Y.; Jordan, D.B.
High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH
Proteins
35
425-439
1999
Pyricularia grisea
Manually annotated by BRENDA team
Motoyama, T.; Imanishi, K.; Yamaguchi, I.
cDNA cloning, expression, and mutagenesis of scytalone dehydratase needed for pathogenicity of the rice blast fungus, Pyricularia oryzae
Biosci. Biotechnol. Biochem.
62
564-566
1998
Pyricularia grisea (P56221)
Manually annotated by BRENDA team
Yamada, N.; Motoyama, T.; Nakasako, M.; Kagabu, S.; Kudo, T.; Yamaguchi, I.
Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus
Biosci. Biotechnol. Biochem.
68
615-621
2004
Pyricularia oryzae
Manually annotated by BRENDA team
Kihara, J.; Moriwaki, A.; Ueno, M.; Tokunaga, T.; Arase, S.; Honda, Y.
Cloning, functional analysis and expression of a scytalone dehydratase gene (SCD1) involved in melanin biosynthesis of the phytopathogenic fungus Bipolaris oryzae
Curr. Genet.
45
197-204
2004
Bipolaris oryzae
Manually annotated by BRENDA team
Okimoto, N.; Nakamura, T.; Suenaga, A.; Futatsugi, N.; Hirano, Y.; Yamaguchi, I.; Ebisuzaki, T.
Cooperative motions of protein and hydration water molecules: molecular dynamics study of scytalone dehydratase
J. Am. Chem. Soc.
126
13132-13139
2004
Pyricularia grisea
Manually annotated by BRENDA team
Suzuki, F.; Arai, M.; Yamaguchi, J.
Genetic analysis of Pyricularia grisea population by rep-PCR during development of resistance to scytalone dehydratase inhibitors of melanin biosynthesis
Plant Dis.
91
176-184
2007
Pyricularia grisea
Manually annotated by BRENDA team
Butler, M.J.; Gardiner, R.B.; Day, A.W.
Melanin synthesis by Sclerotinia sclerotiorum
Mycologia
101
296-304
2009
Sclerotinia sclerotiorum
Manually annotated by BRENDA team
Tseng, M.N.; Chung, P.C.; Tzean, S.S.
Enhancing the stress tolerance and virulence of an entomopathogen by metabolic engineering of dihydroxynaphthalene melanin biosynthesis genes
Appl. Environ. Microbiol.
77
4508-4519
2011
Alternaria alternata, Alternaria alternata BCRC30501
Manually annotated by BRENDA team
Suudi, M.; Park, J.M.; Kang, W.R.; Park, S.R.; Hwang, D.J.; Ahn, I.P.
Quantification of rice brown leaf spot through Taqman real-time PCR specific to the unigene encoding Cochliobolus miyabeanus scytalone dehydratase1 involved in fungal melanin biosynthesis
J. Microbiol.
50
947-954
2012
Bipolaris oryzae (Q7Z8L5), Bipolaris oryzae
Manually annotated by BRENDA team
Saitoh, Y.; Izumitsu, K.; Morita, A.; Shimizu, K.; Tanaka, C.
Cloning of Sal1, a scytalone dehydratase gene involved in melanin biosynthesis in Cochliobolus heterostrophus
Mycoscience
53
330-334
2012
Bipolaris maydis (A0SXQ9), Bipolaris maydis HITO7711 (A0SXQ9)
Manually annotated by BRENDA team
Kimura, N.; Fujimoto, H.
Comparison of scytalone dehydratase activities between scytalone dehydratase inhibitor-sensitive and inhibitor-resistant Magnaporthe oryzae isolates
J. Plant Dis. Protect.
124
525-532
2017
Pyricularia oryzae
-
Manually annotated by BRENDA team
Liang, Y.; Xiong, W.; Steinkellner, S.; Feng, J.
Deficiency of the melanin biosynthesis genes SCD1 and THR1 affects sclerotial development and vegetative growth, but not pathogenicity, in Sclerotinia sclerotiorum
Mol. Plant Pathol.
19
1444-1453
2018
Sclerotinia sclerotiorum (A7F6T4), Sclerotinia sclerotiorum, Sclerotinia sclerotiorum ATCC 18683 / 1980 / Ss-1 (A7F6T4)
Manually annotated by BRENDA team