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4.2.1.94: scytalone dehydratase

This is an abbreviated version!
For detailed information about scytalone dehydratase, go to the full flat file.

Word Map on EC 4.2.1.94

Reaction

Scytalone
=
1,3,8-Trihydroxynaphthalene
+
H2O

Synonyms

dehydratase, scytalone, Sal1, SCD, SCD1, scytalone dehydratase1, SS1G_13314

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.94 scytalone dehydratase

Engineering

Engineering on EC 4.2.1.94 - scytalone dehydratase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F162A
-
crystal structure
V75M
-
inhibition of the mutant enzyme by (1RS,3RS)-2,2-dichloro-N-[(R)-1-(4-chlorophenyl)ethyl]-1-ethyl-3-methylcyclopropanecarboxamide is more than 200fold reduced in comparison with that of the wild-type, about 2fold reduced turnover number for scytalone as compared to wild-type enzyme
additional information