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4.2.1.92: hydroperoxide dehydratase

This is an abbreviated version!
For detailed information about hydroperoxide dehydratase, go to the full flat file.

Word Map on EC 4.2.1.92

Reaction

(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate
=
(9Z,15Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate
 +
H2O

Synonyms

10S-hydroperoxide lyase, 13-HPL, 13-hydroperoxide lyase, 13-hydroperoxide-lyase, 13HPL, 13S-hydroperoxide-dependent peroxidase, 5,8-hydroperoxide isomerase, 8,11-hydroperoxide isomerase, 9-HPL, 9/13 hydroperoxide lyase, 9R-DOX-AOS, 9S-DOX-AOS, allene oxide synthase, allene oxide synthase-1, AOS, AOS1, AOS2, cAOS, catalase-related allene oxide synthase, CmHPL, Csa_7G075590, CsHPL, CYP74, CYP741, CYP742, CYP74A, CYP74B, CYP74B24, CYP74c, CYP74C13_GM, CYP74C13_MT, CYP74C1_CS, CYP74C2, CYP74C31, CYP74C4_ST, cytochrome P450 74A, EC 5.3.99.1, eLOX3, fatty acid 9-hydroperoxide lyase, fatty acid hydroperoxide lyase, fatty acid hydroperoxide-metabolizing enzyme, Fg-cat, FG02216.1, FGSG_02217, FOXB_01332, HPI, HPL, HPL1, HPLS, HPO lyase, HPO-lyase, hydroperoxide dehydrase, hydroperoxide isomerase, hydroperoxide lyase, hydroperoxide lyase 1, hydroperoxidehydrase, isomerase, hydroperoxide, KC525886, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, LOX, Mn-LO, More, MtrunA17_Chr4g0034141, Npun_R5469, OsAOS1, OsHPL3, OsHPL3/CYP74B2, RPP, rubber particle protein

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.92 hydroperoxide dehydratase

Inhibitors

Inhibitors on EC 4.2.1.92 - hydroperoxide dehydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(13S)-hydroperoxyoctadecadienoic acid
Fg-cat is inactivated in the course of the transformation of 13S-hydroperoxyoctadecadienoic acid and reaction is reinitiated by further addition of enzyme, product inhibition
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoic acid
-
irreversible substrate inhibition
CH3HgI
-
-
hexanal
-
irreversible product inhibition, hexanal efficiently and specifically binds to the sulfhydryl groups in the active site of the enzyme through conjugate addition, hexanal seems to form a schiff base with the surface amino groups of the zymoprotein
imidazole
-
imidazole may coordinate to ferric heme iron, triggering a heme-iron transition from high spin state to low spin state
iodoacetic acid
-
-
N-bromosuccinimide
-
-
nordihydroguaiaretic acid
p-chloromercuribenzoate
-
-
additional information
-