4.2.1.9: dihydroxy-acid dehydratase
This is an abbreviated version!
For detailed information about dihydroxy-acid dehydratase, go to the full flat file.
Word Map on EC 4.2.1.9
-
4.2.1.9
-
branched-chain
-
dhads
-
fe-s
-
acetolactate
-
isomeroreductase
-
isobutanol
-
2-ketoisovalerate
-
reductoisomerase
-
2,3-butanediol
-
bcaas
-
ketol-acid
-
ilvbncd
-
drug development
-
analysis
-
synthesis
- 4.2.1.9
-
branched-chain
-
dhads
- fe-s
- acetolactate
-
isomeroreductase
- isobutanol
- 2-ketoisovalerate
- reductoisomerase
- 2,3-butanediol
-
bcaas
-
ketol-acid
-
ilvbncd
- drug development
- analysis
- synthesis
Reaction
Synonyms
2,3-dihydroxy acid hydrolyase, 2,3-dihydroxyisovalerate dehydratase, acetohydroxyacid dehydratase, AfIlv3A, AFUA_2G2410, alpha,beta-dihydroxy acid dehydratase, alpha,beta-dihydroxyisovalerate dehydratase, AT3G23940, DAD, dehydratase, dihydroxy acid, DHAD, dihydroxy acid dehydrase, dihydroxy acid dehydratase, dihydroxyacid dehydratase, H16_A2987, ilvC, IlvD, SsDHAD, VEG110, Vegetative protein 110
ECTree
4.2.1.9 dihydroxy-acid dehydrataseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.2.1.9 - dihydroxy-acid dehydratase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(+)-2,3-dihydroxy-3-ethylpentanoate
?
-
20% of the activity with 2,3-dihydroxyisovalerate
-
-
?
(2R,3R)-2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
-
?
(2R,3S)-2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
-
?
2,3-dihydroxy-3-methylvalerate
3-methyl-2-oxovalerate + H2O
-
-
-
-
?
2,3-dihydroxyisovalerate
2-oxovalerate + H2O
-
IlvD, an iron-sulfur enzyme, catalyses the conversion from 2,3-dihydroxyisovalerate to 2-keto-isovalerate and is essential for the branchend-chain amino acid biosynthesis
-
-
?
threo-2,3-dihydroxybutanoate
?
-
at 45% of the activity with 2,3-dihydroxyisovalerate
-
-
?
2,3-dihydroxy-3-methylbutanoate
2-oxoisovalerate + H2O
-
-
-
?
2,3-dihydroxy-3-methylbutanoate
2-oxoisovalerate + H2O
-
-
-
?
2,3-dihydroxy-3-methylbutanoate
2-oxoisovalerate + H2O
-
-
-
?
2,3-dihydroxy-3-methylbutanoate
2-oxoisovalerate + H2O
-
no activity with 2S-2,3-dihydroxy-3-methylbutanoate
-
?
2,3-dihydroxy-3-methylbutanoate
2-oxoisovalerate + H2O
-
2R-2,3-dihydroxy-3-methylbutanoate
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
i.e. 2-ketoisovalerate
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
-
i.e. 2-ketoisovalerate
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
i.e. alpha-ketoisovalerate
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
i.e. 2-ketoisovalerate, i.e. alpha-ketoisovalerate
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
the enzyme is implicated in latex metabolism
-
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
biosynthesis pathway of the branched chain amino acids valine and isoleucine
-
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H2O
biosynthesis pathway of the branched chain amino acids valine and isoleucine
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
2R,3R-(2,3)-dihydroxy-3-methylpentanoate, at 45% of the activity with 2,3-dihydroxyisovalerate
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
2R,3R-dihydroxy-3-methylpentanoate, 2R,3S-dihydroxy-3-methylpentanoate, no activity with isomers with 2S configuration
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
-
-
?
2,3-dihydroxy-3-methylpentanoate
3-methyl-2-oxopentanoate + H2O
-
2R,3S-2,3-dihydroxy-3-methylpentanoate, 2R,3R-2,3-dihydroxy-3-methylpentanoate
-
-
?
2,3-dihydroxy-3-methylpentanoate
?
-
2R,3R-(2,3)-dihydroxy-3-methylpentanoate
-
-
?
2,3-dihydroxy-3-methylpentanoate
?
-
involved in synthesis of Ile
-
-
?
D-glycerate
pyruvate + H2O
the enzyme catalyzes the non-natural dehydration of D-glycerate to pyruvate
-
-
?
D-glycerate
pyruvate + H2O
the enzyme catalyzes the non-natural dehydration of D-glycerate to pyruvate
-
-
?
additional information
?
-
reaction product determination by formation of 2,4-dinitrophenylhydrazone from the keto acid product resulting in 2-ketoisovalerate-dinitrophenylhydrazone
-
-
?
additional information
?
-
-
reaction product determination by formation of 2,4-dinitrophenylhydrazone from the keto acid product resulting in 2-ketoisovalerate-dinitrophenylhydrazone
-
-
?
additional information
?
-
reaction product determination by formation of 2,4-dinitrophenylhydrazone from the keto acid product resulting in 2-ketoisovalerate-dinitrophenylhydrazone
-
-
?
additional information
?
-
dihydroxy-acid dehydratase is one of the key enzymes involved in the biosynthetic pathway of the branched chain amino acids
-
-
?
additional information
?
-
-
dihydroxy-acid dehydratase is one of the key enzymes involved in the biosynthetic pathway of the branched chain amino acids
-
-
?
additional information
?
-
dihydroxy-acid dehydratase is one of the key enzymes involved in the biosynthetic pathway of the branched chain amino acids
-
-
?
additional information
?
-
-
third enzyme in the branched-chain amino acid biosynthetic pathway
-
-
?
