4.2.1.9: dihydroxy-acid dehydratase
This is an abbreviated version!
For detailed information about dihydroxy-acid dehydratase, go to the full flat file.
Word Map on EC 4.2.1.9
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4.2.1.9
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branched-chain
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dhads
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fe-s
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acetolactate
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isomeroreductase
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isobutanol
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2-ketoisovalerate
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reductoisomerase
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2,3-butanediol
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bcaas
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ketol-acid
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ilvbncd
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drug development
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analysis
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synthesis
- 4.2.1.9
-
branched-chain
-
dhads
- fe-s
- acetolactate
-
isomeroreductase
- isobutanol
- 2-ketoisovalerate
- reductoisomerase
- 2,3-butanediol
-
bcaas
-
ketol-acid
-
ilvbncd
- drug development
- analysis
- synthesis
Reaction
Synonyms
2,3-dihydroxy acid hydrolyase, 2,3-dihydroxyisovalerate dehydratase, acetohydroxyacid dehydratase, AfIlv3A, AFUA_2G2410, alpha,beta-dihydroxy acid dehydratase, alpha,beta-dihydroxyisovalerate dehydratase, AT3G23940, DAD, dehydratase, dihydroxy acid, DHAD, dihydroxy acid dehydrase, dihydroxy acid dehydratase, dihydroxyacid dehydratase, H16_A2987, ilvC, IlvD, SsDHAD, VEG110, Vegetative protein 110
ECTree
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Cofactor
Cofactor on EC 4.2.1.9 - dihydroxy-acid dehydratase
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[2Fe-2S]-center
DHAD can accommodate [Fe2S2] and [Fe4S4] clusters. Only the [Fe2S2] cluster-bound form is catalytically active. The [Fe2S2] cluster is coordinated by at least one non-cysteinyl ligand, which can be replaced by the thiol group(s) of dithiothreitol. [Fe2S2] cluster-containing NFU2 protein is likely the physiological cluster donor for in vivo maturation of DHAD