4.2.1.76: UDP-glucose 4,6-dehydratase

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For detailed information about UDP-glucose 4,6-dehydratase, go to the full flat file.

Reaction

Synonyms

bifunctional UDP-4-keto-6-deoxy-D-glucose epimerase/reductase, GAL102, RHM1, RHM2/MUM4, RHM3, UDP-D-glucose 4,6-dehydratase, UDP-D-glucose-4,6-hydrolyase, UDP-Glc 4,6-dehydratase, UDP-glucose-4,6-dehydratase, UG4,6-Dh, Ugd, UGER

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.76 UDP-glucose 4,6-dehydratase

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Results	in table
1	Activating Compound
25	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
3	Cofactor
4	General Information
9	Inhibitors
3	KM Value [mM]
11	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
9	Organism
3	Pathway
6	pH Optimum
2	pH Range
5	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
9	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
7	Subunits
21	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

General Information

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General Information on EC 4.2.1.76 - UDP-glucose 4,6-dehydratase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

2 entries

malfunction

Candida albicans

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inactivation of GAL102-encoded UDP-glucose 4,6-dehydratase activity causes altered mannosylation of cell wall proteins, loss of cell wall integrity and changes in biofilm characteristics. The reduced virulence of gal102-deficient Candida albicans is associated with ist inability to elicit a strong pro-inflammatory response

730794

physiological function

Candida albicans

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UDP-glucose 4, 6-dehydratase activity plays an important role in maintaining cell wall integrity and virulence of Candida albicans

730794

evolution

Acanthamoeba polyphaga Mimivirus

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phylogenetic analysis indicates that ATCV-1 has probably acquired its UGD gene via a recent horizontal gene transfer from a green algal host, while an earlier event involving the complete pathway probably occurred between a protozoan ancestor and mimivirus. Chloroviruses, and maybe mimivirus, may encode most, if not all, of the glycosylation machinery involved in the synthesis of specific glycan structures essential for virus replication and infection

716065

evolution

Acanthocystis turfacea chlorella virus 1

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phylogenetic analysis indicates that ATCV-1 has probably acquired its UGD gene via a recent horizontal gene transfer from a green algal host, while an earlier event involving the complete pathway probably occurred between a protozoan ancestor and mimivirus. While ATCV-1 lacks an epimerase/reductase gene, its Chlorella host may encode this enzyme. Chloroviruses, and maybe mimivirus, may encode most, if not all, of the glycosylation machinery involved in the synthesis of specific glycan structures essential for virus replication and infection

716065