4.2.1.75: uroporphyrinogen-III synthase

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For detailed information about uroporphyrinogen-III synthase, go to the full flat file.

Word Map on EC 4.2.1.75

4.2.1.75

porphyria

erythropoietic

heme

photosensitivity

5-aminolevulinic

tetrapyrrole

coproporphyrins

delta-aminolevulinic

ferrochelatase

pbgase

mutilate

erythrodontia

transfusion-dependent

protoporphyria

hypertrichosis

urologists

coproporphyrinogen

aymaras

amerindian

Reaction

Synonyms

CobA/HemD, Hydroxymethylbilane hydrolyase [cyclizing], hydroxymethylbilane hydrolyase, cyclizing, Isomerase, uroporphyrinogen, Porphobilinogenase, Synthase, uroporphyrinogen III co-, U3S, URO synthase, uro'gen III synthase, URO-synthase, UROIIIS, Uroporphyrinogen III co-synthase, Uroporphyrinogen III cosynthase, Uroporphyrinogen III synthase, Uroporphyrinogen isomerase, Uroporphyrinogen-III cosynthase, Uroporphyrinogen-III cosynthetase, uroporphyrinogen-III-synthase, UROS

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.75 uroporphyrinogen-III synthase

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Results	in table
4	Activating Compound
21465	AA Sequence
1	CAS Registry Number
20	Cloned(Commentary)
3	Crystallization (Commentary)
319	Disease/ Diagnostics
3	Expression
14	General Information
8	General Stability
38	Inhibitors
4	kcat/KM [mM/s]
14	KM Value [mM]
4	Localization
13	Metals/Ions
26	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
51	Organism
3	Oxidation Stability
8	Pathway
14	PDB ID
16	pH Optimum
4	pH Range
2	Posttranslational Modification
118	Protein Variants
20	Purification (Commentary)
8	Reaction
3	Reaction Type
50	Reference
1	Renatured (Commentary)
22	Source Tissue
11	Specific Activity [micromol/min/mg]
6	Storage Stability
56	Substrates and Products (Substrate)
17	Subunits
65	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Temperature Stability [°C]
8	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 4.2.1.75 - uroporphyrinogen-III synthase

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intermediate cell mass

Danio rerio

Q1ET39

uroporphyrinogen III synthase forms pairs of bilateral stripes in the lateral mesoderm at the 15-somite stage. At 24 h post-fertilization, uroporphyrinogen III synthase is predominantly expressed in the intermediate cell mass (ICM) that is the major site of hematopoiesis. The expression is drastically suppressed in the bloodless mutants cloche and vlad tepes/gata 1 from 15-somite to 24hpf stages, indicating that both cloche abd vlad tepes/gata 1 are required for the induction and maitenance of uroporphyrinogen III synthase expression in intermediate cell mass

679470

K-562 cell

Homo sapiens

erythroleukemia cells

erythroleukemia cells

697884