4.2.1.70: pseudouridylate synthase
This is an abbreviated version!
For detailed information about pseudouridylate synthase, go to the full flat file.
Word Map on EC 4.2.1.70
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4.2.1.70
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pseudouridylation
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baculovirus
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ribonucleoproteins
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congenita
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dyskeratosis
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dyskerin
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rna-guided
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snornps
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rna-modifying
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sideroblastic
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roscovitine
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archaeosine
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gar1
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nop10
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his
- 4.2.1.70
-
pseudouridylation
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baculovirus
- ribonucleoproteins
- congenita
-
dyskeratosis
-
dyskerin
-
rna-guided
-
snornps
-
rna-modifying
-
sideroblastic
- roscovitine
-
archaeosine
- gar1
- nop10
- his
Reaction
Synonyms
16S pseudouridine 516 synthase, 16S pseudouridylate 516 synthase, 5-ribosyluracil 5'-phosphate synthetase, Depressed growth-RATE protein DEG1, IndA, More, ORP protein, Osmoprotectant regulator of PLC, P35 protein, pseudouridine monophosphate synthetase, pseudouridine synthase, pseudouridine synthase I, pseudouridine-5'-phosphate glycosidase, Pseudouridylate synthase, pseudouridylate synthetase, pseudouridylate synthetase I, pseudouridylate synthetase II, pseudouridylic acid synthetase, PSI55 synthase, psi55 tRNA pseudouridine synthase, psiMP synthetase, psisynthetase, psiUMP synthetase, PSUI, PUS, synthase, pseudouridylate, tRNA pseudouridine 55 synthase, TruB, uracil hydrolyase, YeiN
ECTree
4.2.1.70 pseudouridylate synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.2.1.70 - pseudouridylate synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
uracil + D-ribose 5-phosphate
?
-
biosynthetic pathway for pseudouridylic acid and pseudouridine
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-
?
pseudouridine 5' phosphate + H2O
?
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a catabolite-repressible enzyme. Enzyme is involved in the utilization in vivo of exogenous pseudouridine
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-
?
pseudouridine 5' phosphate + H2O
?
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growth on pseudouridine as sole pyrimidine source
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-
?
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
the enzyme is involved in the metabolism of pseudouridine in uropathogenic Escherichia coli
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-
r
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
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the association of IndA with pseudouridine kinase indicates that it serves physiologically to metabolize pseudouridine 5'-phosphate rather than to form it
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-
r
uridinyl-tRNA
pseudouridinyl-tRNA
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TruB is specific for the nearly universal psi55 in tRNA
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?
uridinyl-tRNA
pseudouridinyl-tRNA
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TruB is specific for the nearly universal psi55 in tRNA
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?
additional information
?
-
-
mutation of the genlocus hisT causes lack of pseudouridylate synthetase activity. The defect in this enzyme leads to the absence of pseudouridines in the anticodon loop of several tRNA species
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-
?
additional information
?
-
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pseudouridine synthase I activity is missing in extracts of strain EB146 (leuK16)
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-
?
additional information
?
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genetic link between tRNA pseudouridine modification and vitamin B6 biosynthesis
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-
?
additional information
?
-
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the enzyme catalyzes pseudouridylation at position 55 in the T-pseudouridine-C arm of all elongator tRNAs
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-
?
additional information
?
-
-
pseudouridine synthase I activity is missing in extracts of strain EB146 (leuK16)
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-
?
additional information
?
-
-
pseudouridine synthase Pus1p displays a multisite substrate specificity
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-
?
additional information
?
-
-
pseudouridine synthase Pus1p displays a multisite substrate specificity
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-
?
additional information
?
-
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pseudouridine synthase Pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA
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-
?
additional information
?
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pseudouridine synthase Pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA
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-
?
additional information
?
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pseudouridylate synthetase I is responsible for the biosynthesis of pseudouridine in the anticodon region of several tRNA species
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-
?
additional information
?
-
-
pseudouridylate synthetase I is responsible for the biosynthesis of pseudouridine in the anticodon region of several tRNA species
-
-
?
additional information
?
-
-
inaccurate protein synthesis in a mutant of Salmonella typhimurium defective in transfer RNA pseudouridylation
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-
?
additional information
?
-
-
pseudouridylate synthetase II is responsible for the biosynthesis of pseudouridine in the TpsiCG loop of every tRNA molecule
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?
additional information
?
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inaccurate protein synthesis in a mutant of Salmonella typhimurium defective in transfer RNA pseudouridylation
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-
?
