4.2.1.68: L-fuconate dehydratase

This is an abbreviated version!
For detailed information about L-fuconate dehydratase, go to the full flat file.

Reaction

Synonyms

dehydratase, L-fuconate, FucD, gaaB, L-fuconate hydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.68 L-fuconate dehydratase

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Results	in table
5153	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	General Stability
12	Inhibitors
10	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
6	Organism
4	Pathway
4	PDB ID
3	pH Optimum
1	pH Range
2	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
4	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
29	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.1.68 - L-fuconate dehydratase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-altronate

?

Xanthomonas campestris

-

-

678170

-

-

?

D-arabinonate

?

Xanthomonas campestris

-

dehydration of D-arabinonate is initiated by abstraction of the 2-proton by Lys220

678170

-

-

?

D-arabonate

2-keto-3-deoxy-D-arabonate + H2O

Sus scrofa

-

-

33951

-

33951

?

D-gluconate

?

2 entries

D-Glucuronate

?

2 entries

D-mannonate

2-dehydro-3-deoxy-D-mannonate + H2O

Aspergillus niger

G3Y683

-

747890

-

-

?

D-ribonate

?

Xanthomonas campestris

-

dehydrations of D-ribonate is initiated by abstraction of the 2-proton by His351

678170

-

-

?

L-arabonate

2-dehydro-3-deoxy-L-arabonate + H2O

Sus scrofa

-

-

33951

-

-

?

L-fuconate

2-dehydro-3-deoxy-L-fuconate + H2O

4 entries

L-Fuconate

?

4 entries

L-fuconate + H2O

2-dehydro-3-deoxy-L-fuconate

Aspergillus niger

G3Y683

highly preferred enzyme

747890

-

-

?

L-galactonate

2-dehydro-3-deoxy-L-galactonate + H2O

2 entries

L-galactonate

2-keto-3-deoxy-L-galactonate + H2O

3 entries

L-mannonate

2-dehydro-3-deoxy-L-mannonate + H2O

Aspergillus niger

G3Y683

-

747890

-

-

?

L-talonate

?

Xanthomonas campestris

-

dehydrations of L-talonate is initiated by abstraction of the 2-proton by His351

678170

-

-

?

additional information

?

-

2 entries

D-gluconate

?

Aspergillus niger

G3Y683

-

747890

-

-

?

D-gluconate

?

Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7

G3Y683

-

747890

-

-

?

D-Glucuronate

?

Aspergillus niger

G3Y683

-

747890

-

-

?

D-Glucuronate

?

Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7

G3Y683

-

747890

-

-

?

L-fuconate

2-dehydro-3-deoxy-L-fuconate + H2O

Aureobasidium pullulans

-

-

33953

-

-

?

L-fuconate

2-dehydro-3-deoxy-L-fuconate + H2O

Sus scrofa

-

-

33952

-

-

?

L-fuconate

2-dehydro-3-deoxy-L-fuconate + H2O

Sus scrofa

-

-

33951

-

33951

ir

L-fuconate

2-dehydro-3-deoxy-L-fuconate + H2O

Xanthomonas campestris

-

FucD reaction involves initial abstraction of the 2-proton by Lys220, acid catalysis of the vinylogous beta-elimination of the 3-OH group by His351, and stereospecific ketonization of the resulting enol, likely by the conjugate acid of Lys220, to yield the 2-keto-3-deoxy-L-fuconate product

678170

-

-

?

L-Fuconate

?

Aspergillus niger

G3Y683

-

747890

-

-

?

L-Fuconate

?

Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7

G3Y683

-

747890

-

-

?

L-Fuconate

?

Aureobasidium pullulans

-

catabolism of L-fucose

33953

-

-

?

L-Fuconate

?

Sus scrofa

-

catabolism of L-fucose

33951, 33952

-

-

?

L-galactonate

2-dehydro-3-deoxy-L-galactonate + H2O

Aspergillus niger

G3Y683

-

747890

-

-

?

L-galactonate

2-dehydro-3-deoxy-L-galactonate + H2O

Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7

G3Y683

-

747890

-

-

?

L-galactonate

2-keto-3-deoxy-L-galactonate + H2O

Aureobasidium pullulans

-

-

33953

-

33953

?

L-galactonate

2-keto-3-deoxy-L-galactonate + H2O

Sus scrofa

-

-

33952

-

33952

?

L-galactonate

2-keto-3-deoxy-L-galactonate + H2O

Xanthomonas campestris

-

dehydration of L-galactonate is initiated by abstraction of the 2-proton by Lys220

678170

-

-

?

additional information

?

-

Aspergillus niger

G3Y683

the L-galactonate dehydratase shows highest activity with L-fuconate. The production of 2-dehydro-3-deoxy sugar is measured with the thiobarbituric acid assay. Substrate specificity analysis, overview. No activity with L-rhamnonate, D-gulonate, L-gulonate, D-arabonate, D-lyxonate, L-lyxonate, D-xylonate, mucic acid, D-riborate, L-arabonate, D-galactonate, and D-galacturonate

747890

-

-

?

additional information

?

-

Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7

G3Y683

the L-galactonate dehydratase shows highest activity with L-fuconate. The production of 2-dehydro-3-deoxy sugar is measured with the thiobarbituric acid assay. Substrate specificity analysis, overview. No activity with L-rhamnonate, D-gulonate, L-gulonate, D-arabonate, D-lyxonate, L-lyxonate, D-xylonate, mucic acid, D-riborate, L-arabonate, D-galactonate, and D-galacturonate

747890

-

-

?