4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

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For detailed information about 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, go to the full flat file.

Reaction

Synonyms

3-hydroxyacyl-ACP dehydratase, AT5G60335, beta-hydroxyacyl-[ACP] dehydratase, Beta-hydroxyoctanoyl-ACP-dehydrase, Beta-Hydroxyoctanoyl-acyl carrier protein dehydrase, D-3-Hydroxyoctanoyl-acyl carrier protein dehydratase, Dehydratase, beta-hydroxyoctanoyl thioester, Dehydratase, D-3-hydroxyoctanoyl-[acyl carrier protein], EC 4.2.1.58, EC 4.2.1.60, EC 4.2.1.61, FabA, FabZ, fatty acid dehydratase, HaHAD1, HaHAD2

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

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Results	in table
40041	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Crystallization (Commentary)
1	Expression
6	General Information
1	Inhibitors
6	kcat/KM [mM/s]
3	KM Value [mM]
1	Localization
3	Natural Substrates/ Products (Substrates)
7	Organism
31	Pathway
143	PDB ID
2	pH Optimum
1	pI Value
4	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 4.2.1.59 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

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SYSTEMATIC NAME

IUBMB Comments

(3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)

This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates [4].