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4.2.1.47: GDP-mannose 4,6-dehydratase

This is an abbreviated version!
For detailed information about GDP-mannose 4,6-dehydratase, go to the full flat file.

Word Map on EC 4.2.1.47

Reaction

GDP-alpha-D-mannose
=
GDP-4-dehydro-alpha-D-rhamnose
+
H2O

Synonyms

ATCV-1GMD, bceN, Dm-gmd, GDP-alpha-D-mannose 4,6-dehydratase, GDP-D-mannose 4,6-dehydratase, GDP-D-mannose 4-oxido-6-reductase, GDP-D-mannose dehydratase, GDP-D-mannose-4,6-dehydratase, GDP-mannose 4, 6-dehydratase, GDP-mannose 4,6 dehydratase, GDP-mannose 4,6-dehydratase, GDP-mannose dehydratase, GDP-mannose dehydrogenase, GDP-mannose-4,6-dehydratase, GMD, GMDS, guanosine 5'-diphosphate-D-mannose 4,6-dehydratase, Guanosine 5'-diphosphate-D-mannose oxidoreductase, Guanosine diphosphomannose 4,6-dehydratase, Guanosine diphosphomannose oxidoreductase, L-GMD, M-GMD, MUR1, ORF13.7, PBCV-1 GMD, S-GMD

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.47 GDP-mannose 4,6-dehydratase

Inhibitors

Inhibitors on EC 4.2.1.47 - GDP-mannose 4,6-dehydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
50% inhibition
Cu2+
5 mM, strong inhibition; strong inhibition at 5 mM
Fe2+
5 mM, strong inhibition; strong inhibition at 5 mM
GDP-alpha-D-mannose
substrate inhibition
GDP-D-glucose
GDP-fucose
-
competitive inhibition
GDP-L-fucose
GDP-L-glucose
competitive
GMP
-
90% inhibition
ITP
-
90% inhibition
Mg2+
high concentrations of MgCl2 (25 mM) have an inhibitory effect on enzyme activity
Mn2+
-
90% inhibition
NADP+
Ni2+
-
90% inhibition
p-chloromercuriphenylsulfonate
-
-
p-hydroxymercuribenzoate
-
-
additional information
-