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4.2.1.47: GDP-mannose 4,6-dehydratase

This is an abbreviated version!
For detailed information about GDP-mannose 4,6-dehydratase, go to the full flat file.

Word Map on EC 4.2.1.47

Reaction

GDP-alpha-D-mannose
=
GDP-4-dehydro-alpha-D-rhamnose
 +
H2O

Synonyms

ATCV-1GMD, bceN, Dm-gmd, GDP-alpha-D-mannose 4,6-dehydratase, GDP-D-mannose 4,6-dehydratase, GDP-D-mannose 4-oxido-6-reductase, GDP-D-mannose dehydratase, GDP-D-mannose-4,6-dehydratase, GDP-mannose 4, 6-dehydratase, GDP-mannose 4,6 dehydratase, GDP-mannose 4,6-dehydratase, GDP-mannose dehydratase, GDP-mannose dehydrogenase, GDP-mannose-4,6-dehydratase, GMD, GMDS, guanosine 5'-diphosphate-D-mannose 4,6-dehydratase, Guanosine 5'-diphosphate-D-mannose oxidoreductase, Guanosine diphosphomannose 4,6-dehydratase, Guanosine diphosphomannose oxidoreductase, L-GMD, M-GMD, MUR1, ORF13.7, PBCV-1 GMD, S-GMD

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.47 GDP-mannose 4,6-dehydratase

Disease

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Disease on EC 4.2.1.47 - GDP-mannose 4,6-dehydratase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Glycomic Profiling Highlights Increased Fucosylation in Pseudomyxoma Peritonei.
Cerebral Hemorrhage
Protein fucosylation is required for Notch dependent vascular integrity in zebrafish.
Colonic Neoplasms
Deficiency of GMD leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling.
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation.
Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis.
Colorectal Neoplasms
Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis.
Cystic Fibrosis
Alginate biosynthetic enzymes in mucoid and nonmucoid Pseudomonas aeruginosa: overproduction of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase by overexpression of the phosphomannose isomerase (pmi) gene.
Control of alginate synthesis in Pseudomonas aeruginosa: regulation of the algR1 gene.
Dehydration
A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.
Preparative synthesis of GDP-beta-L-fucose by recombinant enzymes from enterobacterial sources.
Infections
Evolution and comparative genomics of Campylobacter jejuni ST-677 clonal complex.
Neoplasm Metastasis
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation.
Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis.
Neoplasms
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation.
Tuberculosis
Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex.
Virus Diseases
Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose.