4.2.1.46: dTDP-glucose 4,6-dehydratase

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For detailed information about dTDP-glucose 4,6-dehydratase, go to the full flat file.

Reaction

Synonyms

DesIV, dTDP-D-glucose 4,6-dehydratase, dTDP-D-glucose oxidoreductase, dTDP-glucose-4,6-dehydratase, dTGD, RmbB, rml-2, RmlB, TDP-D-glucose 4,6-dehydratase, TDP-glucose oxidoreductase, TDPDH, Thymidine diphosphate D-glucose oxidoreductase, thymidine diphosphate-glucose 4,6-dehydratase, Thymidine diphospho-D-glucose 4,6-dehydratase, Thymidine diphosphoglucose oxidoreductase, UDP-D-glucose 4,6-dehydratase, Ugd

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.46 dTDP-glucose 4,6-dehydratase

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Results	in table
1	Activating Compound
36877	AA Sequence
7	Application
1	CAS Registry Number
11	Cloned(Commentary)
25	Cofactor
4	Crystallization (Commentary)
6	General Information
2	General Stability
2	IC50 Value
37	Inhibitors
4	Ki Value [mM]
48	KM Value [mM]
4	Metals/Ions
22	Molecular Weight [Da]
64	Natural Substrates/ Products (Substrates)
83	Organism
31	Pathway
35	PDB ID
14	pH Optimum
2	pH Range
1	pH Stability
35	Protein Variants
21	Purification (Commentary)
1	Reaction
1	Reaction Type
82	Reference
13	Specific Activity [micromol/min/mg]
7	Storage Stability
105	Substrates and Products (Substrate)
13	Subunits
111	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
51	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.2.1.46 - dTDP-glucose 4,6-dehydratase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

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Escherichia coli

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5719

sitting-drop vapour-diffusion technique. Diffraction data obtained to a resolution of 2.8 A on a single frozen RmlB crystal which belongs to space group P2(1) with unit-cell parameters a = 111.85, b = 87.77, c = 145.66 A, beta = 131.53°

Salmonella enterica

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649133

structure determined to 2.47 A resolution with its cofactor NAD+ bound, sitting drop method

Salmonella enterica

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652851

wild-type and mutant enzyme D128N/E129Q crystallized as a complex with NAD+ and the substrate dTDP-glucose

Streptomyces venezuelae

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652536