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4.2.1.40: glucarate dehydratase

This is an abbreviated version!
For detailed information about glucarate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.40

Reaction

D-glucarate
=
5-dehydro-4-deoxy-D-glucarate
+
H2O

Synonyms

D-Glucarate dehydratase, dehydratase, glucarate, GDH, glucarate dehydratase, GlucD

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.40 glucarate dehydratase

Engineering

Engineering on EC 4.2.1.40 - glucarate dehydratase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D366A
reduced kcat for D-glucarate and L-idarate
D366N
reduced kcat for D-glucarate and 3fold reduced kcat for L-idarate
H339A
reduced kcat for D-glucarate and L-idarate
H339N
reduced kcat for D-glucarate and L-idarate
H339Q
reduced kcat for D-glucarate and L-idarate
K207Q
reduced kcat for D-glucarate and L-idarate
K207R
reduced kcat for D-glucarate and L-idarate
N341D
do not catalyze the dehydrofluorination of 4-deoxy-4-fluoro-D-glucarate
N341L
catalyzes the dehydrofluorination of 4-deoxy-4-fluoro-D-glucarate
Y150F
significant reduction of kcat for D-glucarate and L-idarate