4.2.1.39: gluconate dehydratase
This is an abbreviated version!
For detailed information about gluconate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.39
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4.2.1.39
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entner-doudoroff
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aldolase
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hyperthermophilic
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sulfolobus
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archaeon
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solfataricus
-
non-phosphorylative
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2-keto-3-deoxygluconate
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synthesis
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kdg
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galactose
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thermoacidophilic
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dehydration
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d-glyceraldehyde
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2-keto-3-deoxy-d-gluconate
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2-keto-3-deoxy-6-phosphogluconate
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epimers
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picrophilus
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galactonate
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torridus
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tenax
-
aldol
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d-glucose
-
halophilic
-
pasteurianum
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embden-meyerhof
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thermoproteus
- 4.2.1.39
-
entner-doudoroff
- aldolase
-
hyperthermophilic
-
sulfolobus
- archaeon
- solfataricus
-
non-phosphorylative
- 2-keto-3-deoxygluconate
- synthesis
- kdg
- galactose
-
thermoacidophilic
- dehydration
- d-glyceraldehyde
- 2-keto-3-deoxy-d-gluconate
- 2-keto-3-deoxy-6-phosphogluconate
-
epimers
-
picrophilus
- galactonate
- torridus
- tenax
-
aldol
- d-glucose
-
halophilic
- pasteurianum
-
embden-meyerhof
-
thermoproteus
Reaction
Synonyms
D-gluconate dehydratase, dehydratase, gluconate, GAD, GlcD, gluconate dehydratase, GNAD, HVO_1488, TTX1156, TTX_1156
ECTree
4.2.1.39 gluconate dehydrataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.1.39 - gluconate dehydratase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-galactoheptonate
2-dehydro-3-deoxy-D-galactoheptonate + H2O
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1.6% of the activity with D-gluconate
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
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substrate specificity 14%
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
low activity
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
low activity
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
2.8% of the activity with D-gluconate. Studies by other groups reveal a catalytic efficiency of 20% for D-galactonate compared to D-gluconate
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
-
substrate specificity 100%
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
-
-
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
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key enzyme in the non-phosphorylated Entner-Doudoroff pathway
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
-
-
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
-
-
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
no activity with D-galactopnate and D-xylonate
-
-
?
D-gluconate
2-dehydro-3-deoxy-D-gluconate + H2O
no activity with D-galactopnate and D-xylonate
-
-
?
D-gluconate
?
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first enzyme in modified Entner-Doudoroff pathway
-
-
?
D-gluconate
?
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involved in conventional Entner-Doudoroff pathway for gluconate utilization
-
-
?
D-gluconate
?
-
first enzyme in modified Entner-Doudoroff pathway
-
-
?
additional information
?
-
-
specific for aldonic acids with 5 or 6 carbon atoms, having hydroxyl groups at C-2 and C-3 in L-threo configuration, no activity with various other compounds tested
-
-
?
additional information
?
-
-
specific for aldonic acids with 5 or 6 carbon atoms, having hydroxyl groups at C-2 and C-3 in L-threo configuration, no activity with various other compounds tested
-
-
?
additional information
?
-
-
only substrate is D-gluconate, not: D-galactonate, D-galactarate, D-galacturonate, 6-phospho-D-gluconate, D-arabonate, D-xylonate, L-mannonate, D-glucoheptonate
-
-
?
additional information
?
-
the enzyme catalyzes the specific dehydration of gluconate and does not utilize galactonate at significant rates
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-
?
additional information
?
-
-
the enzyme catalyzes the specific dehydration of gluconate and does not utilize galactonate at significant rates
-
-
?
additional information
?
-
the enzyme catalyzes the specific dehydration of gluconate and does not utilize galactonate at significant rates
-
-
?
additional information
?
-
xylonate (10 mM) is not utilized
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-
?
additional information
?
-
-
gluconate dehydratase being active only with C6 metabolites
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-
?
additional information
?
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-
gluconate dehydratase being active only with C6 metabolites
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-
?
