4.2.1.39: gluconate dehydratase
This is an abbreviated version!
For detailed information about gluconate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.39
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4.2.1.39
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entner-doudoroff
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aldolase
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hyperthermophilic
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sulfolobus
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archaeon
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solfataricus
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non-phosphorylative
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2-keto-3-deoxygluconate
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synthesis
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kdg
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galactose
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thermoacidophilic
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dehydration
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d-glyceraldehyde
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2-keto-3-deoxy-d-gluconate
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2-keto-3-deoxy-6-phosphogluconate
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epimers
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picrophilus
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galactonate
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torridus
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tenax
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aldol
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d-glucose
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halophilic
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pasteurianum
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embden-meyerhof
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thermoproteus
- 4.2.1.39
-
entner-doudoroff
- aldolase
-
hyperthermophilic
-
sulfolobus
- archaeon
- solfataricus
-
non-phosphorylative
- 2-keto-3-deoxygluconate
- synthesis
- kdg
- galactose
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thermoacidophilic
- dehydration
- d-glyceraldehyde
- 2-keto-3-deoxy-d-gluconate
- 2-keto-3-deoxy-6-phosphogluconate
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epimers
-
picrophilus
- galactonate
- torridus
- tenax
-
aldol
- d-glucose
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halophilic
- pasteurianum
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embden-meyerhof
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thermoproteus
Reaction
Synonyms
D-gluconate dehydratase, dehydratase, gluconate, GAD, GlcD, gluconate dehydratase, GNAD, HVO_1488, TTX1156, TTX_1156
ECTree
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General Information
General Information on EC 4.2.1.39 - gluconate dehydratase
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metabolism
physiological function
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the enzyme is involved in the non-phosphorylative version of the Entner-Doudoroff pathway, overview. In vitro kinetic analyses of glucose dehydrogenase, gluconate dehydratase, and KDG-aldolase from Sulfolobus solfataricus show, that these enzymes are also capable of catalyzing the catabolism of galactose, the C4 epimer of glucose, to pyruvate and glyceraldehyde. Gluconate dehydratase is active only with C6 metabolites, thus it is not involved in the C5-specific branch of the non-phosphorylative version of the Entner-Doudoroff pathway
metabolism
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the enzyme is involved in the non-phosphorylative version of the Entner-Doudoroff pathway, overview. In vitro kinetic analyses of glucose dehydrogenase, gluconate dehydratase, and KDG-aldolase from Sulfolobus solfataricus show, that these enzymes are also capable of catalyzing the catabolism of galactose, the C4 epimer of glucose, to pyruvate and glyceraldehyde. Gluconate dehydratase is active only with C6 metabolites, thus it is not involved in the C5-specific branch of the non-phosphorylative version of the Entner-Doudoroff pathway
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a knockout mutant of GAD loses the ability to grow on glucose. Following a prolonged incubation period, GAD is functionally replaced by xylonate dehydratase
physiological function
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a knockout mutant of GAD loses the ability to grow on glucose. Following a prolonged incubation period, GAD is functionally replaced by xylonate dehydratase
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