4.2.1.33: 3-isopropylmalate dehydratase
This is an abbreviated version!
For detailed information about 3-isopropylmalate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.33
Reaction
Synonyms
3-isopropylmalate dehydratase, 3-isopropylmalate isomerase, Alpha-IPM isomerase, alpha-isopropylmalate isomerase, beta-Isopropylmalate dehydratase, dehydratase,beta-isopropylmalate, IPM dehydratase, IPM isomerase, IPMI, IPMI SSU1, isopropylmalate dehydratase, isopropylmalate isomerase, LEU1S, leuC, LeuCD, LeuD, MJ0499, More, SOI10, Superoxide-inducible protein 10
ECTree
4.2.1.33 3-isopropylmalate dehydrataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.1.33 - 3-isopropylmalate dehydratase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2R,3S)-3-isopropylmalate
(2S)-2-isopropylmalate
the isopropylmalate isomerase small subunit of the hyperthermophilic archaea Pyrococcus horikoshii (PhIPMI-s) functions as isopropylmalate isomerase in the leucine biosynthesis pathway, and as homoaconitase (HACN) in the lysine biosynthesis pathway via alpha-aminoadipic acid
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-
?
(2R,3S)-3-isopropylmalate
2-isopropylmaleate + H2O
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-
-
?
(2S)-2-isopropylmalate
(2R,3S)-3-isopropylmalate
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-
-
?
(2S)-2-isopropylmalate
(2R,3S)-3-isopropylmalate
isomerization via a dehydration and a hydration step
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-
?
(2S)-2-isopropylmalate
(2R,3S)-3-isopropylmalate
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-
-
?
(2S)-2-isopropylmalate
(2R,3S)-3-isopropylmalate
isomerization via a dehydration and a hydration step
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-
?
(2S)-2-isopropylmalate + H2O
(2R,3S)-3-isopropylmalate
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-
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?
(2S)-2-isopropylmalate + H2O
(2R,3S)-3-isopropylmalate
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-
?
2-isopropylmaleate + H2O
3-isopropylmalate
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?
2-isopropylmaleate + H2O
?
-
second of three reactions of leucine biosynthesis
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?
2-isopropylmaleate + H2O
?
-
high activities in leu-1 mutants which have accumulated great amounts of inducer
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?
2-isopropylmaleate + H2O
?
-
second of three reactions of leucine biosynthesis
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?
2-isopropylmaleate + H2O
?
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second of three reactions of leucine biosynthesis
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?
2-isopropylmaleate + H2O
?
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second of three reactions of leucine biosynthesis
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?
3-isopropylmalate
2-isopropylmaleate + H2O
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-
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
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NMR and mass spectrometric compound determination and analysis, overview
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?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmalate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled
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-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmalate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled
-
-
?
additional information
?
-
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmalate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled
-
-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmaleate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled. The LeuD residues 30-37 form the substrate discriminating loop, and LeuD residues 70-74 the substrate binding loop
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-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmaleate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled. The LeuD residues 30-37 form the substrate discriminating loop, and LeuD residues 70-74 the substrate binding loop
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-
?
additional information
?
-
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmaleate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled. The LeuD residues 30-37 form the substrate discriminating loop, and LeuD residues 70-74 the substrate binding loop
-
-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmaleate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled. The LeuD residues 30-37 form the substrate discriminating loop, and LeuD residues 70-74 the substrate binding loop
-
-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmaleate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled. The LeuD residues 30-37 form the substrate discriminating loop, and LeuD residues 70-74 the substrate binding loop
-
-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmalate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled
-
-
?
additional information
?
-
the functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmalate to beta-isopropylmalate, the active site is only completely formed after LeuC and LeuD have assembled
-
-
?
additional information
?
-
-
citrate, aconitate, isocitrate are not substrates
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?
additional information
?
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citrate, aconitate, isocitrate are not substrates
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-
?
