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4.2.1.33: 3-isopropylmalate dehydratase

This is an abbreviated version!
For detailed information about 3-isopropylmalate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.33

Reaction

(2R,3S)-3-isopropylmalate
=
(2S)-2-isopropylmalate

Synonyms

3-isopropylmalate dehydratase, 3-isopropylmalate isomerase, Alpha-IPM isomerase, alpha-isopropylmalate isomerase, beta-Isopropylmalate dehydratase, dehydratase,beta-isopropylmalate, IPM dehydratase, IPM isomerase, IPMI, IPMI SSU1, isopropylmalate dehydratase, isopropylmalate isomerase, LEU1S, leuC, LeuCD, LeuD, MJ0499, More, SOI10, Superoxide-inducible protein 10

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.33 3-isopropylmalate dehydratase

Inhibitors

Inhibitors on EC 4.2.1.33 - 3-isopropylmalate dehydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
recovery after restoration of lower ionic strength shows hysteresis effect
1,10-phenanthroline
-
16% inhibition at 0.1 mM
8-hydroxyquinolinesulfonate
-
16% inhibition at 0.1 mM
beta-carboxy-beta-hydroxyisocaproate
Cd2+
-
complete inhibition at 1 mM
Co2+
-
3% inhibition at 1 mM
cysteine
dimethylmesaconate
-
-
Fe2+
-
13% inhibition at 1 mM
glutathione
isopropylmalate
KF
-
most potent inhibitor
mercaptoethanol
Mg2+
-
26% inhibition at 1 mM
Mn2+
-
45% inhibition at 1 mM
N-ethylmaleimide
sulfhydryl compounds
Zn2+
-
complete inhibition at 1 mM
additional information
-