4.2.1.31: maleate hydratase

This is an abbreviated version!
For detailed information about maleate hydratase, go to the full flat file.

Reaction

Synonyms

D-malate hydro-lyase, HbzIJ, malease, maleic-acid hydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.31 maleate hydratase

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Results	in table
4	Activating Compound
8	AA Sequence
5	Application
1	CAS Registry Number
1	Cloned(Commentary)
2	General Information
2	General Stability
41	Inhibitors
5	Ki Value [mM]
7	KM Value [mM]
2	Localization
7	Metals/Ions
8	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
42	Organism
2	Pathway
8	PDB ID
34	pH Optimum
2	pH Range
1	pH Stability
4	Purification (Commentary)
30	Reaction
2	Reaction Type
40	Reference
4	Source Tissue
3	Specific Activity [micromol/min/mg]
54	Substrates and Products (Substrate)
7	Subunits
5	Synonyms
1	Systematic Name
35	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 4.2.1.31 - maleate hydratase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2,3-dimethylmaleate

?

Pseudomonas oleovorans

-

0.8% of turnover of maleate, equlibrium constant: 11.2

5647

-

-

?

bromomaleate

(-)-erythro((2S, 3S)-3-)-bromomalate

2 entries

chloromaleate

(-)-erythro((2S, 3S)-3-)-chloromalate

2 entries

citraconate

D-citramalate

4 entries

DL-malate

maleate

Zea mays

-

16-25% of turnover in opposite direction

5642

-

5642

?

maleate

(R)-malate

4 entries

maleate

?

30 entries

maleate + H2O

(R)-malate

6 entries

maleic acid + H2O

(R)-malic acid

Pseudomonas oleovorans

-

-

5646

-

-

?

additional information

?

-

Pseudomonas oleovorans

-

maleate counterion greatly affects enzyme activity and solute substrate concentration, Ca2+ at 750 mM optimal, followed by Mg2+

5645

-

-

?

bromomaleate

(-)-erythro((2S, 3S)-3-)-bromomalate

Arthrobacter sp.

-

-

5648

-

-

?

bromomaleate

(-)-erythro((2S, 3S)-3-)-bromomalate

Arthrobacter sp. MCI2612

-

-

5648

-

-

?

chloromaleate

(-)-erythro((2S, 3S)-3-)-chloromalate

Arthrobacter sp.

-

-

5648

-

-

?

chloromaleate

(-)-erythro((2S, 3S)-3-)-chloromalate

Arthrobacter sp. MCI2612

-

-

5648

-

-

?

citraconate

D-citramalate

Arthrobacter sp.

-

-

5648

-

5648

?

citraconate

D-citramalate

Arthrobacter sp. MCI2612

-

-

5648

-

5648

?

citraconate

D-citramalate

Pseudomonas oleovorans

-

-

5645

-

5645

?

citraconate

D-citramalate

Pseudomonas oleovorans

-

54% of turnover of maleate, equlibrium constant: 104

5647

-

5647

?

maleate

(R)-malate

Oryctolagus cuniculus

-

-

5641

-

5641

?

maleate

(R)-malate

Oryctolagus cuniculus

-

-

5643

-

5643

?

maleate

(R)-malate

Oryctolagus cuniculus

-

threo-D-malate-3-d

5644

-

-

?

maleate

(R)-malate

Pseudomonas oleovorans

-

equilibrium constant: 2050

5647

-

-

?

maleate

?

Acinetobacter sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Actinoplanes sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Aspergillus sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Brevibacterium sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Candida sp. (in: Saccharomycetales)

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Corynebacterium sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Exophiala sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Hansenula sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Klebsiella sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Micrococcus sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Mycobacterium sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Nocardia sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Oryctolagus cuniculus

-

product enters citric acid cycle

5643

-

-

?

maleate

?

Penicillium sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Phanerochaete sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Pichia sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Pleurotus sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Proteus sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Pseudomonas oleovorans

-

-

5646

-

-

?

maleate

?

Pseudomonas oleovorans

-

involved in 3-hydroxybenzoate degradation, enzyme is induced when organism grows on 3-hydroxybenzoate, growth-cycle dependent, maleate is no growth substrate due to lack of system for transport into cell

5650

-

-

?

maleate

?

Pseudomonas sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Rhodotorula sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Saccharomyces sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Schizosaccharomyces sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Sporobolomyces sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Streptomyces sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Trichosporon sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Xanthobacter sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Yarrowia sp.

-

possibly involved in salvaging pathway of pyridine nucleotides under conditions of nutrient depletion

5646

-

-

?

maleate

?

Zea mays

-

metabolic role

5642

-

-

?

maleate + H2O

(R)-malate

Arthrobacter sp.

-

-

5648, 5649

-

-

r

maleate + H2O

(R)-malate

Arthrobacter sp. MCI2612

-

-

5648, 5649

-

-

r

maleate + H2O

(R)-malate

Pseudomonas alcaligenes

Q0QFQ7; Q0QFQ6

-

746830

-

-

?

maleate + H2O

(R)-malate

Pseudomonas alcaligenes

Q0QFQ7; Q0QFQ6

the enzyme is involved in maleylpyruvate catabolism in the gentisate pathway

746830

-

-

?

maleate + H2O

(R)-malate

Pseudomonas alcaligenes NCIMB 9867

Q0QFQ7; Q0QFQ6

-

746830

-

-

?

maleate + H2O

(R)-malate

Pseudomonas alcaligenes NCIMB 9867

Q0QFQ7; Q0QFQ6

the enzyme is involved in maleylpyruvate catabolism in the gentisate pathway

746830

-

-

?