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4.2.1.3: aconitate hydratase

This is an abbreviated version!
For detailed information about aconitate hydratase, go to the full flat file.

Word Map on EC 4.2.1.3

Reaction

citrate
=
cis-aconitate
 +
H2O

Synonyms

Acn, AcnA, AcnA3, AcnB, ACO, Aco1, Aco2, Aco3, ACO4, acon, aconitase, aconitase 2, aconitase A, aconitase B, aconitase/2-methylaconitate hydratase, Aconitate hydratase, AH, c-acon, c-aconitase, CAA, cis-aconitase, citB, citrate hydro-lyase, cytoplasmic aconitase, cytoplasmic aconitase/iron regulatory protein 1 homolog, EC 4.2.1.4, Ferritin repressor protein, hydratase, aconitate, IP210, IRE-BP, Iron regulatory protein, iron regulatory protein 1, iron regulatory-like protein, iron-regulatory protein 1, iron-responsive element binding protein, IRP, IRP-1, IRP1, mACON, Major iron-containing protein, MICP, More, PfIRPa, SPBP4H10.15

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.3 aconitate hydratase

Expression

Expression on EC 4.2.1.3 - aconitate hydratase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
acetate and ethanol as sole carbon sources and in high iron conditions induce the enzyme
acnA expression is enhanced in an acnB mutant
-
citramalate significantly increases citrate content and reduces the mitochondrial isozyme activity, while slightly inducing its protein level, oxalomalate also slightly upregulates the enzyme
-
expression of acnA is repressed by the presence of acnB
-
promoter fusion experiments show that acnA expression is regulated by the cyclic-AMP receptor protein, the fumarate nitrate reduction regulator, the ferric uptake regulator and the superoxide response protein
-
the gene is upregulated during infection by Candidatus Leiberibacter asiaticus
-