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4.2.1.3: aconitate hydratase

This is an abbreviated version!
For detailed information about aconitate hydratase, go to the full flat file.

Word Map on EC 4.2.1.3

Reaction

citrate
=
cis-aconitate
 +
H2O

Synonyms

Acn, AcnA, AcnA3, AcnB, ACO, Aco1, Aco2, Aco3, ACO4, acon, aconitase, aconitase 2, aconitase A, aconitase B, aconitase/2-methylaconitate hydratase, Aconitate hydratase, AH, c-acon, c-aconitase, CAA, cis-aconitase, citB, citrate hydro-lyase, cytoplasmic aconitase, cytoplasmic aconitase/iron regulatory protein 1 homolog, EC 4.2.1.4, Ferritin repressor protein, hydratase, aconitate, IP210, IRE-BP, Iron regulatory protein, iron regulatory protein 1, iron regulatory-like protein, iron-regulatory protein 1, iron-responsive element binding protein, IRP, IRP-1, IRP1, mACON, Major iron-containing protein, MICP, More, PfIRPa, SPBP4H10.15

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.3 aconitate hydratase

Crystallization

Crystallization on EC 4.2.1.3 - aconitate hydratase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of enzyme-fluorocitrate complex
-
2.4 A structure of AcnB, hanging drop vapor diffusion at 17°C
aconitase form of bifunctional enzyme, evaluation of model for iron regulatory form of enzyme and its binding to iron-responsive elements
recombinant enzyme, hanging-drop vapour-diffusion method. An X-ray fluorescence measurement performed on a gold-derivative crystal shows the unexpected presence of zinc, in addition to gold and iron
-
structure of human IRP1 in its aconitase form and tentative model of an IRP1-iron-responsive element complex
molecular modeling suggests acetylation at K144 may perturb the tertiary structure of the enzyme
1.8 A resolution crystal structure of the S642A:citrate complex of mitochondrial aconitase
computational modeling of aconitase inactivation by superoxide and nitric oxide
-
crystallographic evidence for a three-iron center
-