4.2.1.3: aconitate hydratase

This is an abbreviated version!
For detailed information about aconitate hydratase, go to the full flat file.

Word Map on EC 4.2.1.3

4.2.1.3

iron-sulfur

transferrin

tricarboxylic

dismutase

fe-s

succinate

tca

malate

citric

cardiac

rna-binding

neurodegenerative

frataxin

krebs

fumarase

friedreich

heme

ataxia

parkinson

overload

iron-dependent

alpha-ketoglutarate

stem-loops

fluorocitrate

bioenergetics

ferroportin

county

hepcidin

peroxynitrite

mnsod

fluoroacetate

georgia

cluster-containing

iron-deficient

iscu

iron-replete

iron-induced

iron-mediated

alabama

kennedy

itaconic

ferrochelatase

cubane

desulfurase

nadp-isocitrate

rna-protein

iron-related

soxrs

l-ferritin

isopropylmalate

medicine

environmental protection

synthesis

biotechnology

Reaction

Synonyms

Acn, AcnA, AcnA3, AcnB, ACO, Aco1, Aco2, Aco3, ACO4, acon, aconitase, aconitase 2, aconitase A, aconitase B, aconitase/2-methylaconitate hydratase, Aconitate hydratase, AH, c-acon, c-aconitase, CAA, cis-aconitase, citB, citrate hydro-lyase, cytoplasmic aconitase, cytoplasmic aconitase/iron regulatory protein 1 homolog, EC 4.2.1.4, Ferritin repressor protein, hydratase, aconitate, IP210, IRE-BP, Iron regulatory protein, iron regulatory protein 1, iron regulatory-like protein, iron-regulatory protein 1, iron-responsive element binding protein, IRP, IRP-1, IRP1, mACON, Major iron-containing protein, MICP, More, PfIRPa, SPBP4H10.15

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.3 aconitate hydratase

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Results	in table
10	Activating Compound
55872	AA Sequence
7	Application
1	CAS Registry Number
30	Cloned(Commentary)
4	Cofactor
12	Crystallization (Commentary)
825	Disease/ Diagnostics
7	Expression
26	General Information
4	General Stability
10	IC50 Value
105	Inhibitors
3	kcat/KM [mM/s]
30	Ki Value [mM]
64	KM Value [mM]
101	Localization
42	Metals/Ions
37	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
460	Organism
3	Oxidation Stability
10	Pathway
29	PDB ID
31	pH Optimum
7	pH Range
6	pI Value
12	Posttranslational Modification
38	Protein Variants
42	Purification (Commentary)
1	Reaction
1	Reaction Type
178	Reference
103	Source Tissue
20	Specific Activity [micromol/min/mg]
4	Storage Stability
156	Substrates and Products (Substrate)
32	Subunits
132	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
8	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.2.1.3 - aconitate hydratase

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cysteine

Rattus rattus

enzyme activity increases 2-4fold in presence of both Fe2+ and cysteine. 0.1-1 mM Fe2+ and 0.05-0.5 mM cysteine

650272

Fe4-S4 cluster

2 entries

ferric ammonium citrate

Homo sapiens

increases activity and gene expression

666327

hemin

Homo sapiens

increases activity and gene expression

666327

lipoic acid

Rattus norvegicus

causes an increase in cardiac enzyme activity at doses of 35 and 70 mg/kg of 1.3 and 2.4fold in the animals

696162

menadione sodium bisulfite

Mus musculus

causes a modest activation of IRP-1 to bind to iron resonsive elements within 15-30 min. Menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the classical Fe-S cluster switch and exerts multiple effects on cellular iron metabolism

651975

additional information

6 entries