4.2.1.28: propanediol dehydratase
This is an abbreviated version!
For detailed information about propanediol dehydratase, go to the full flat file.
Word Map on EC 4.2.1.28
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4.2.1.28
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cobiialamin
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oxytoca
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cyanocobalamin
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5'-deoxyadenosine
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homolysis
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propionaldehyde
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1,2-ethanediol
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hydroxocobalamine
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cobamide
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5,6-dimethylbenzimidazole
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cobalt-carbon
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microcompartment
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spectator
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base-on
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carbon-cobalt
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corrins
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5\'-deoxyadenosyl
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acetobacterium
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synthesis
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degradation
- 4.2.1.28
-
cobiialamin
- oxytoca
- cyanocobalamin
- 5'-deoxyadenosine
-
homolysis
- propionaldehyde
- 1,2-ethanediol
-
hydroxocobalamine
- cobamide
- 5,6-dimethylbenzimidazole
-
cobalt-carbon
-
microcompartment
-
spectator
-
base-on
-
carbon-cobalt
-
corrins
-
5\'-deoxyadenosyl
- acetobacterium
- synthesis
- degradation
Reaction
Synonyms
1,2-propanediol dehydratase, 1,2-propanediol hydro-lyase, adenosylcobalamin-dependent diol dehydratase, AdoCbl-dependent diol dehydratase, cobalamin-dependent diol dehydratase, coenzyme B12-dependent diol dehydrase, coenzyme B12-dependent diol dehydratase, coenzyme-B12-dependent diol dehydratase, DDH, dehydratase, diol, dehydratase, propanediol, diol dehydrase, diol dehydratase, diol dehydratase alpha subunit, dioldehydrase, dioldehydratase, DL-1,2-propanediol hydro-lyase, DL-1,2-propanediol hydrolyase, GldCDE, meso-2,3-butanediol dehydrase, PduCDE, PduCDEGH, Propanediol dehydrase
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Subunits
Subunits on EC 4.2.1.28 - propanediol dehydratase
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heptamer
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2 * 60000, 1 * 51000, 2 * 29000, 2 * 15000, SDS-PAGE, subunit stoichiometry confirmed by N-terminal amino acid analysis
heterohexamer
hexamer
oligomer
additional information
heterohexamer
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2 * 61100 + 2 * 35000 + 2 * 19800, SDS-PAGE
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hexamer
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alpha2beta2gamma2, 2 * 60000, 2 * 30000, 2 * 19000, SDS-PAGE, recombinant enzyme, beta2 is F component, alpha2gamma2 is S component, mutual effects on folding
hexamer
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dimer of heterotrimers, contained within the R-subunit is an (a/b) beta-barrel that houses the active site
hexamer
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alpha2beta2gamma2, 2 * 63000 + 2 * 28000 + 2 * 22000, SDS-PAGE
three different subunits encoded by distinct genes
oligomer
three different subunits encoded by distint genes
oligomer
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x * 28071, x * 60348, x * 24113, x * 19173, estimated from nucleotide sequences of cloned genes
additional information
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dimer of a heterotrimer, alphabetagamma2. The enzyme dissociates into two dissimilar protein components, F and S, upon DEAE-cellulose chromatography in the absence of substrate, which are identified as the monomeric beta subunit and the trimeric alpha2gamma2 complex, respectively
additional information
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dissociation of protein into components S and F which are not identical with individual subunits, dissociation retarded by substrate, both components necessary for coenzyme binding
additional information
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F consisits of one polypeptide, S of at least four subunits, x * 60000, x * 23000, x * 15500, x * 14000, Cys, Lys, His, andArg residues essential for catalysis
additional information
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role of 60000 and 29000 subunits as membrane anchors, role of 51000 subunit for coenzyme binding
additional information
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membrane-associated protein also dissociates into F and S components, both are not preparation artefacts, cytoplasmic subunits of lower MW may have underwent proteolysis, possible presence of hinge regions in tertiary structure
additional information
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N-terminal amino acid analysis, role of cysteines
additional information
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N-terminal amino acid analysis, role of cysteines
additional information
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reassociatin of components F and S strongly promoted by substrate, component S is a sulfhydryl protein
additional information
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subunits also in immunodiffusion tests, N-terminal amino acid analysis
additional information
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dimer of a heterotrimer, alphabetagamma2. The enzyme dissociates into two dissimilar protein components, F and S, upon DEAE-cellulose chromatography in the absence of substrate, which are identified as the monomeric beta subunit and the trimeric alpha2gamma2 complex, respectively