4.2.1.28: propanediol dehydratase
This is an abbreviated version!
For detailed information about propanediol dehydratase, go to the full flat file.
Word Map on EC 4.2.1.28
-
4.2.1.28
-
cobiialamin
-
oxytoca
-
cyanocobalamin
-
5'-deoxyadenosine
-
homolysis
-
propionaldehyde
-
1,2-ethanediol
-
hydroxocobalamine
-
cobamide
-
5,6-dimethylbenzimidazole
-
cobalt-carbon
-
microcompartment
-
spectator
-
base-on
-
carbon-cobalt
-
corrins
-
5\'-deoxyadenosyl
-
acetobacterium
-
synthesis
-
degradation
- 4.2.1.28
-
cobiialamin
- oxytoca
- cyanocobalamin
- 5'-deoxyadenosine
-
homolysis
- propionaldehyde
- 1,2-ethanediol
-
hydroxocobalamine
- cobamide
- 5,6-dimethylbenzimidazole
-
cobalt-carbon
-
microcompartment
-
spectator
-
base-on
-
carbon-cobalt
-
corrins
-
5\'-deoxyadenosyl
- acetobacterium
- synthesis
- degradation
Reaction
Synonyms
1,2-propanediol dehydratase, 1,2-propanediol hydro-lyase, adenosylcobalamin-dependent diol dehydratase, AdoCbl-dependent diol dehydratase, cobalamin-dependent diol dehydratase, coenzyme B12-dependent diol dehydrase, coenzyme B12-dependent diol dehydratase, coenzyme-B12-dependent diol dehydratase, DDH, dehydratase, diol, dehydratase, propanediol, diol dehydrase, diol dehydratase, diol dehydratase alpha subunit, dioldehydrase, dioldehydratase, DL-1,2-propanediol hydro-lyase, DL-1,2-propanediol hydrolyase, GldCDE, meso-2,3-butanediol dehydrase, PduCDE, PduCDEGH, Propanediol dehydrase
ECTree
4.2.1.28 propanediol dehydrataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.1.28 - propanediol dehydratase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R,S)-1,2-propanediol
propanal + H2O
-
-
-
-
?
1,2-propanediol
propionaldehyde + H2O
-
-
-
-
?
glycolaldehyde hydrate
ethandiol
-
-
-
?
1,2-butanediol
butyraldehyde
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formation of ternary complex between apoenzyme, coenzyme and substrate analogue
-
-
?
1,2-propanediol
propanal
-
the substrate is located near to K+ rather than to the cobalt atom of cobalamin
-
?
1,2-propanediol
propanal
-
L-propanediol reacts faster than D-isomer in competitive reactions, D-isomer reacts faster than L-isomer if both are introduced alone, explanation: D-isomer has hindered access to catalytic site, but is processed faster once bound
-
?
1,2-propanediol
propanal
-
-
-
?
1,2-propanediol
propanal + H2O
-
-
-
-
?
butane-1,2-diol
?
107% activity compared to propane-1,2-diol
-
-
?
propane-1,2-diol
propanal + H2O
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Co-C bond formation during reaction
-
-
?
propane-1,2-diol
propanal + H2O
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substrate binding structure and mechanism, overview
-
-
?
propane-1,2-diol
propanal + H2O
-
regulatory control mechanism, overview
-
-
?
additional information
?
-
-
the enzyme catalyze the conversion of 1,2-diols, such as 1,2-propanediol, ethanediol and glycerol, to the corresponding aldehydes
-
-
?
additional information
?
-
-
hydrogen bonding interaction between the hydroxyl group on C2 of substrate and the side chain of residue Hisalpha143 is important not only for catalysis but also for protecting radical intermediates, overview
-
-
?
additional information
?
-
-
Asp335 has a strong anticatalytic effect on the OH group migration despite its important role in substrate binding. The synergistic interplay of the O-C bond cleavage by Ca2+ ion and the deprotonation of the spectator OH-group by Glu170 is required to overcome the anticatalytic effect of Asp335
-
-
?
additional information
?
-
no activity with hexane-1,2-diol
-
-
?
additional information
?
-
-
substrate stabilizes apoenzyme-coenzyme association
-
-
?
additional information
?
-
-
production of both electron acceptor and intermediate for fermentative oxidation of 1,2-diols
-
-
?
additional information
?
-
-
functional role in glycerol fermentation, mechanism of control, induced by dihydroxyacetone
-
-
?
additional information
?
-
-
metabolic role: production of electron acceptor beta-hydroxypropionaldehyde
-
-
?
additional information
?
-
-
the enzyme catalyze the conversion of 1,2-diols, such as 1,2-propanediol, ethanediol and glycerol, to the corresponding aldehydes
-
-
?
additional information
?
-
-
the enzyme catalyze the conversion of 1,2-diols, such as 1,2-propanediol, ethanediol and glycerol, to the corresponding aldehydes
-
-
?
additional information
?
-
-
specific for 1,2-ethanediol and 1,2-propanediol
-
-
?
