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4.2.1.28: propanediol dehydratase

This is an abbreviated version!
For detailed information about propanediol dehydratase, go to the full flat file.

Word Map on EC 4.2.1.28

Reaction

Propane-1,2-diol
=
propanal
+
H2O

Synonyms

1,2-propanediol dehydratase, 1,2-propanediol hydro-lyase, adenosylcobalamin-dependent diol dehydratase, AdoCbl-dependent diol dehydratase, cobalamin-dependent diol dehydratase, coenzyme B12-dependent diol dehydrase, coenzyme B12-dependent diol dehydratase, coenzyme-B12-dependent diol dehydratase, DDH, dehydratase, diol, dehydratase, propanediol, diol dehydrase, diol dehydratase, diol dehydratase alpha subunit, dioldehydrase, dioldehydratase, DL-1,2-propanediol hydro-lyase, DL-1,2-propanediol hydrolyase, GldCDE, meso-2,3-butanediol dehydrase, PduCDE, PduCDEGH, Propanediol dehydrase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.28 propanediol dehydratase

Application

Application on EC 4.2.1.28 - propanediol dehydratase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
degradation
-
possible use in anaerobic polyethylene glycol degradation
synthesis
-
production of 2-butanol, using a TEV-protease based expression system to achieve equimolar expression of the B12-dependent dehydratase subunit and use of NADH-dependent secondary alcohol dehydrogenase Sadh from Gordonia sp. able to catalyze the subsequent conversion of butanone to 2-butanol. A final concentration of 460.2 mg/l 2-butanol and 260.1 mg/l of butanone is found. Availability of NADH is achieved by growing cells lacking the GPD1 and GPD2 isogenes under anaerobic conditions