4.2.1.28: propanediol dehydratase
This is an abbreviated version!
For detailed information about propanediol dehydratase, go to the full flat file.
Word Map on EC 4.2.1.28
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4.2.1.28
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cobiialamin
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oxytoca
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cyanocobalamin
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5'-deoxyadenosine
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homolysis
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propionaldehyde
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1,2-ethanediol
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hydroxocobalamine
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cobamide
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5,6-dimethylbenzimidazole
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cobalt-carbon
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microcompartment
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spectator
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base-on
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carbon-cobalt
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corrins
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5\'-deoxyadenosyl
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acetobacterium
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synthesis
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degradation
- 4.2.1.28
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cobiialamin
- oxytoca
- cyanocobalamin
- 5'-deoxyadenosine
-
homolysis
- propionaldehyde
- 1,2-ethanediol
-
hydroxocobalamine
- cobamide
- 5,6-dimethylbenzimidazole
-
cobalt-carbon
-
microcompartment
-
spectator
-
base-on
-
carbon-cobalt
-
corrins
-
5\'-deoxyadenosyl
- acetobacterium
- synthesis
- degradation
Reaction
Synonyms
1,2-propanediol dehydratase, 1,2-propanediol hydro-lyase, adenosylcobalamin-dependent diol dehydratase, AdoCbl-dependent diol dehydratase, cobalamin-dependent diol dehydratase, coenzyme B12-dependent diol dehydrase, coenzyme B12-dependent diol dehydratase, coenzyme-B12-dependent diol dehydratase, DDH, dehydratase, diol, dehydratase, propanediol, diol dehydrase, diol dehydratase, diol dehydratase alpha subunit, dioldehydrase, dioldehydratase, DL-1,2-propanediol hydro-lyase, DL-1,2-propanediol hydrolyase, GldCDE, meso-2,3-butanediol dehydrase, PduCDE, PduCDEGH, Propanediol dehydrase
ECTree
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Activating Compound
Activating Compound on EC 4.2.1.28 - propanediol dehydratase
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additional information
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ADP and ATP analogues are not able to substitute ATP significantly
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ATP
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absolutely required for the reactivation of the inactivated holoenzyme by the reactivating factor
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activates inactive enzymeCN-Cbl complexes, dimeric (alphabbeta) structurea large subunit of 64 kDa and a small subunit of 14 kDa
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diol dehydratase-reactivating factor
both dehydratase-reactivating factors exist as alpha2beta2 heterotetramers, DdrA or GdrA and DdrB or GdrB, respectively. The diol dehydratase DD-reactivating factor reactivates the inactivated holoenzyme in the presence of ATP and Mg2+ by mediating the exchange of the tightly bound damaged cofactor for free intact coenzyme, overview. Mechanism of the reactivation of inactivated holoenzymes by reactivating factors, overview. The enzyme does not form a complex with the reactivating factor while it exists as an active holoenzyme. The reactivating factor binds ATP and hydrolyzes it to ADP by its own weak ATPase activity. The resulting ADP-bound form of the reactivating factor has a high affinity for the enzyme, and interacts with the inactivated holoenzyme to form a tight apoenzyme/reactivating factor complex, with the concomitant release of the damaged cofactor. The reactivating factor reverts to a low-affinity form through the replacement of bound ADP by free ATP, resulting in the dissociation of the apoenzyme/reactivating factor complex into apoenzyme and the reactivating factor, kinetics, overview
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diol dehydratase-reactivating factor
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activates inactive enzymeCN-Cbl complexes, dimeric (alphabeta) structurea large subunit of 64000 Da and a small subunit of 14000 Da
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