4.2.1.27: acetylenecarboxylate hydratase

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For detailed information about acetylenecarboxylate hydratase, go to the full flat file.

Reaction

Synonyms

acetylenemonocarboxylic acid hydrase, dehydratase, malonate semialdehyde, EC 4.2.1.71, malonate semialdehyde dehydratase, malonate semialdehyde dehydratase, malonate semialdehyde, malonate-semialdehyde dehydratase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.27 acetylenecarboxylate hydratase

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Results	in table
1	AA Sequence
1	CAS Registry Number
8	Inhibitors
1	KM Value [mM]
1	Organism
4	Pathway
1	pH Optimum
1	pH Range
1	pH Stability
1	Purification (Commentary)
1	Reaction
2	Reaction Type
1	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
1	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 4.2.1.27 - acetylenecarboxylate hydratase

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3-oxopropanoate hydro-lyase (propynoate-forming)

The reaction is effectively irreversible, favouring oxopropanoate (malonic semialdehyde) and its tautomers. Also acts on but-3-ynoate forming acetoacetate. The mechanism appears to involve hydration of the acetylene to 3-hydroxypropenoate, which will spontaneously tautomerize to 3-oxopropanoate. It is thus analogous to EC 4.1.1.78, acetylenedicarboxylate decarboxylase, in its mechanism.