4.2.1.19: imidazoleglycerol-phosphate dehydratase

This is an abbreviated version!
For detailed information about imidazoleglycerol-phosphate dehydratase, go to the full flat file.

Reaction

Synonyms

dehydratase, imidazoleglycerol phosphate, His3, HisB, HisN5B, IGP dehydratase, IGPD, imidazoleglycerol phosphate dehydratase, imidazoleglycerolphoshate dehydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.19 imidazoleglycerol-phosphate dehydratase

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Results	in table
3	Activating Compound
34630	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
4	General Stability
20	Inhibitors
4	Ki Value [mM]
9	KM Value [mM]
1	Localization
10	Metals/Ions
16	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
33	Organism
1	Oxidation Stability
6	Pathway
137	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
1	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
33	Reference
6	Source Tissue
3	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
10	Subunits
16	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.1.19 - imidazoleglycerol-phosphate dehydratase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

27 entries

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

?

Neurospora crassa

-

-

5538

-

-

?

additional information

?

-

3 entries

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Arabidopsis thaliana

-

-

5542, 5545

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Brassica oleracea

-

-

5540

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Cryptococcus neoformans

-

-

5541

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Cryptococcus neoformans

P0CO22

removal of a non-acidic hydrogen atom in the dehydration reaction

652527

-

652527

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Escherichia coli

-

-

5530

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Escherichia coli

-

-

5544

-

5544

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Hordeum vulgare

-

-

5540

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Kazachstania humilis

H9C4A4

-

730174

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Kazachstania humilis CBS 8195

H9C4A4

-

730174

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Mycobacterium tuberculosis

-

-

728872

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Neurospora crassa

-

-

5538

-

5538

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Oryza sativa

-

-

5540

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Rosa sp.

-

-

5540

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Saccharomyces cerevisiae

-

-

5532

-

5532

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Saccharomyces cerevisiae

-

-

5533

-

5533

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Saccharomyces cerevisiae

-

-

5534

-

5534

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Saccharomyces cerevisiae

-

-

5543, 5546

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5530

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5531

-

5531

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5535

-

5535

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5536

-

5536

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5537

-

5537

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Staphylococcus aureus

-

-

5536

-

5536

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Trichoderma harzianum

-

-

5539

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Triticum aestivum

-

-

5540

-

5540

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Triticum aestivum

-

-

5545, 5547

-

-

?

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

Zea mays

-

-

5540

-

-

?

additional information

?

-

Arabidopsis thaliana

O23346

mechanism shows an enzyme-catalyzed formation of a high-energy imidazolate intermediate. Changes in manganese coordination chemistry dominate all aspects of catalysis. In the first part of the reaction, the enzyme harnesses the substrate binding energy to create a distorted, ligand-depleted metal center, which serves to remove kinetic barriers to the production of the imidazolate intermediate. Subsequently, a second switch in coordination chemistry restores the octahedral coordination of the metal ion, leading to critical torsion angle changes to the substrate that are necessary for concomitant production of the diazafulvene

749384

-

-

?

additional information

?

-

Arabidopsis thaliana

-

mechanism shows an enzyme-catalyzed formation of a high-energy imidazolate intermediate. Changes in manganese coordination chemistry dominate all aspects of catalysis. In the first part of the reaction, the enzyme harnesses the substrate binding energy to create a distorted, ligand-depleted metal center, which serves to remove kinetic barriers to the production of the imidazolate intermediate. Subsequently, a second switch in coordination chemistry restores the octahedral coordination of the metal ion, leading to critical torsion angle changes to the substrate that are necessary for concomitant production of the diazafulvene

749384

-

-

?

additional information

?

-

Cryptococcus neoformans

P0CO22

sixth step in histidine biosynthesis

652527

-

652527

?