4.2.1.171: cis-L-3-hydroxyproline dehydratase

This is an abbreviated version!
For detailed information about cis-L-3-hydroxyproline dehydratase, go to the full flat file.

Reaction

Synonyms

AcnX, AcnX type IIa, C3LHyp dehydratase, c3LHypD, cis-3-hydroxy-L-proline dehydratase, cis-L-3-hydroxyproline hydro-lyase, SIAM614_28497

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.171 cis-L-3-hydroxyproline dehydratase

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Results	in table
9	AA Sequence
4	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
8	kcat/KM [mM/s]
8	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
7	Organism
1	Pathway
2	Protein Variants
4	Purification (Commentary)
1	Reaction
7	Reference
7	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
3	Subunits
21	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.1.171 - cis-L-3-hydroxyproline dehydratase

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cis-3-hydroxy-L-proline

1-pyrroline-2-carboxylate + H2O

7 entries

additional information

Roseibium aggregatum

A0NXQ8

the enzyme catalyzes the competing 2-epimerization to trans-3-hydroxy-D-proline (1,1-proton transfer) and dehydration to 1-pyrroline-2-carboxylate (beta-elimination), with eventual total dehydration. The reactions are initiated by abstraction of the alpha-proton of the substrate. The rate of epimerization is about 1.5fold greater than that of dehydration at substrate concentrations both below and above the value of the KM. No substrates: L-proline and stereoisomers of 3-hydroxyproline, 4-hydroxyproline and their mono- and di-N-methylated derivatives

740574