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4.2.1.17: enoyl-CoA hydratase

This is an abbreviated version!
For detailed information about enoyl-CoA hydratase, go to the full flat file.

Word Map on EC 4.2.1.17

Reaction

(3S)-3-hydroxyacyl-CoA
=
trans-2(or 3)-enoyl-CoA
 +
H2O

Synonyms

(R)-specific 2-enoyl-CoA hydratase, 2,3-dehydroadipyl-CoA hydratase, 2-enoyl-CoA hydratase, 2-enoyl-CoA hydratase 1, 2-enoyl-CoA hydratase-1, 2-enoyl-hydratase 1, 2-octenoyl coenzyme A hydrase, acyl coenzyme A hydrase, AIM1, AMECH, beta-hydroxyacid dehydrase, beta-hydroxyacyl-CoA dehydrase, CCH/HBCD, classic 2-enoyl-CoA hydratase, crotonase, crotonyl hydrase, crotonyl-CoA hydratase, D-3-hydroxyacyl-CoA dehydratase, DELTA2-enoyl-CoA hydratase-1, ECH, ECH-1, ECH-2, ECH1, ECH2, ECHS1, enol-CoA hydratase, Enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), enoyl coenzyme A hydratase, enoyl coenzyme A hydratase (L), enoyl coenzyme A hydratase 1, enoyl hydrase, enoyl-CoA hydratase, enoyl-CoA hydratase 1, enoyl-CoA hydratase 2, enoyl-CoA hydratase short chain 1, enoyl-CoA hydratase/isomerase, enoyl-coenzyme A hydratase, enoyl-coenzyme A hydratase/isomerase, FadB', FadRBs, H16_A0461, hydratase, enoyl coenzyme A, mECH-1, MFP2, mitochondrial enoyl coenzyme A hydratase, mitochondrial short-chain enoyl-CoA hydratase, mitochondrial short-chain enoyl-CoA hydratase-1, More, multifunctional enzyme type 1, PaaF, PBE, PBFE, perMFE-1, perMFE-I, peroxisomal bifunctional enzyme, peroxisomal multifunctional enzyme, type 1, R-3-hydroxyacyl-CoA enoyl-CoA hydratase, R-3-hydroxyacyl-CoA enoyl-CoA hydratases, rat peroxisomal multifunctional enzyme type 1, rpMFE1, S-3-hydroxyacyl-CoA enoyl-CoA hydratase, S-3-hydroxyacyl-CoA enoyl-CoA hydratases, SCEH, short chain enoyl coenzyme A hydratase, short-chain enoyl-CoA hydratase, trans-2-enoyl-CoA hydratase, unsaturated acyl-CoA hydratase, YsiA

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.17 enoyl-CoA hydratase

Inhibitors

Inhibitors on EC 4.2.1.17 - enoyl-CoA hydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3S)-hydroxybutanoyl-CoA
-
competitive
(3S)-hydroxyhexadecanoyl-CoA
-
competitive, 50% inhibition at 0.00075 mM, 90% inhibition by 0.004 mM
(R)-methylenecyclopropylformyl-CoA
-
methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1
(S)-methylenecyclopropylformyl-CoA
-
methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1
3-ketohexadecanoyl-CoA
-
0.008 mM, 40% inhibition
3-octynoyl-CoA
-
irreversibly inactivates only enoyl-CoA hydratase 2, the catalytic residue Glu47 is covalently labeled by the inhibitor
acetoacetyl-CoA
acetyl-CoA
0.1 mM, 70% inhibition
CoA
0.1 mM, 30% inhibition
decenoyl-CoA
-
-
hexadecenoyl-CoA
-
-
hexenoyl-CoA
-
-
iodoacetamide
-
10 mM, 20 min, 20% inhibition
methylenecyclopropylformyl-CoA
-
a metabolite derived from a natural amino acid, (methylenecyclopropyl)glycine, that inactivates enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2. Competence of (R)- and (S)-MCPF-CoA to inactivate the ECH2 and kinetic analysis, enzyme-inhibitor complex structures, mass spectrometric analysis, inhibition mechanism, overview
NEM
-
10 mM, 19% inhibition. 5 mM, 13% inhibition
octanoyl-CoA
p-chloromercuribenzoate
-
1 mM, complete inhibition. 0.1 mM, 11% inhibition
propanoyl-CoA
0.1 mM, 60% inhibition
propionyl-CoA
0.1 mM, 60% inhibition
additional information
-