4.2.1.168: GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase

This is an abbreviated version!
For detailed information about GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase, go to the full flat file.

Reaction

2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol]

2-GDP-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol]

Synonyms

colD, GDP-4-keto-6-deoxy-D-mannose-3-dehydratase, WbdK

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.168 GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase

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Results	in table
30	AA Sequence
1	Cloned(Commentary)
1	Cofactor
3	Crystallization (Commentary)
1	General Information
4	Organism
2	Pathway
2	Protein Variants
4	Reaction
4	Reference
5	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 4.2.1.168 - GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase

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GDP-4-dehydro-alpha-D-rhamnose + L-glutamate

GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + 2-oxoglutarate + ammonia

3 entries

GDP-D-perosamine + L-glutamate

GDP-4-dehydro-3,6-dideoxymannose + 2-oxoglutarate + ammonia

Escherichia coli

Q9F118

738573

wild-type ColD is able to catalyze the production of GDP-4-keto-3,6-dideoxymannose using GDP-perosamine instead of GDP-4-keto-6-deoxymannose as a substrate

additional information

Yersinia pseudotuberculosis

G4WJD4

enzyme functions as GDP-4-keto-6-deoxy-D-mannose-3-dehydrase responsible for C-3 deoxygenation of GDP-4-keto-6-deoxy-D-mannose. The enzyme is coenzyme B6-dependent and catalysis is initiated by a transamination step in which pyridoxal 5'-phosphate is converted to pyridoxamine 5'-phosphate in the presene of L-glutamate. This coenzyme forms a Schiff base with the keto sugar substrate and the resulting adduct undergoes a pyridoxamine 5'-phosphate-mediated beta-dehydration reaction to give a sugar enamine intermediate, which after tautomerization and hydrolysis to release ammonia yields GDP-4-keto-3,6-dideoxy-D-mannose as the product

721596