4.2.1.159: dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
This is an abbreviated version!
For detailed information about dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase, go to the full flat file.
Reaction
Synonyms
D-olivose, D-oliose and D-mycarose 2,3-dehydratase, EryBV, evaA, jadO, megBVI, mtmV, oleV, spnO, TDP-4-keto-6-deoxy-D-glucose 2,3-dehydratase
ECTree
4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydrataseAdvanced search results
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General Information on EC 4.2.1.159 - dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
physiological function
physiological function
enzyme is involved in synthesis of the dideoxysugar component of jadomycin B. Insertion mutants show a single major peak corresponding to jadomycin aglycone
physiological function
in forosamine biosynthesis, enzymes SpnO and SpnN function as a 2,3-dehydrase and a 3-ketoreductase, respectively. The two enzymes act sequentially to catalyze C-2 deoxygenation of TDP-4-dehydro-6-deoxy-D-glucose to form the SpnQ substrate, TDP-4-dehydro-2,6-dideoxy-D-glucose
physiological function
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production of TDP-L-megosamine from TDP-4-keto-6-deoxy-D-glucose requires only five biosynthetic steps, catalyzed by MegBVI, MegDII, MegDIII, MegDIV, and MegDV
physiological function
the mtm-v gene encodes for a 2,3-dehydratase that catalyzes early and common steps in the biosyntheiss of the mithramycin sugars D-olivose, D-oliose and D-mycarose. Its inactivation causes the accumulation of the nonglycosylated intermediate premithramycinone
physiological function
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enzyme is involved in synthesis of the dideoxysugar component of jadomycin B. Insertion mutants show a single major peak corresponding to jadomycin aglycone
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