4.2.1.159: dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
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For detailed information about dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase, go to the full flat file.
Reaction
Synonyms
D-olivose, D-oliose and D-mycarose 2,3-dehydratase, EryBV, evaA, jadO, megBVI, mtmV, oleV, spnO, TDP-4-keto-6-deoxy-D-glucose 2,3-dehydratase
ECTree
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Application
Application on EC 4.2.1.159 - dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
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synthesis
construction of a Streptomyces albus strain harboring the oleG2 glycosyltransferase gene and transformation with plasmid constructs containing a set of genes proposed to be required for the biosynthesis of dTDP-L-olivose and dTDP-L-oleandrose, respectively. Incubation of these strains with the erythromycin aglycon (erythronolide B) gives rise to two new glycosylated compounds, identified as L-3-O-olivosyl- and L-3-O-oleandrosyl-erythronolide B. Plasmid constructs pOLV and pOLE containing the oleW, oleV, oleL, oleS, oleE, and oleU genes and the 5' end of oleNI encode all enzyme activities required for the biosynthesis of these two 2,6-dideoxysugars