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4.2.1.159: dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

This is an abbreviated version!
For detailed information about dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase, go to the full flat file.

Reaction

dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose
=
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose

Synonyms

D-olivose, D-oliose and D-mycarose 2,3-dehydratase, EryBV, evaA, jadO, megBVI, mtmV, oleV, spnO, TDP-4-keto-6-deoxy-D-glucose 2,3-dehydratase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

Application

Application on EC 4.2.1.159 - dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
construction of a Streptomyces albus strain harboring the oleG2 glycosyltransferase gene and transformation with plasmid constructs containing a set of genes proposed to be required for the biosynthesis of dTDP-L-olivose and dTDP-L-oleandrose, respectively. Incubation of these strains with the erythromycin aglycon (erythronolide B) gives rise to two new glycosylated compounds, identified as L-3-O-olivosyl- and L-3-O-oleandrosyl-erythronolide B. Plasmid constructs pOLV and pOLE containing the oleW, oleV, oleL, oleS, oleE, and oleU genes and the 5' end of oleNI encode all enzyme activities required for the biosynthesis of these two 2,6-dideoxysugars