4.2.1.158: galactarate dehydratase (D-threo-forming)

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For detailed information about galactarate dehydratase (D-threo-forming), go to the full flat file.

Reaction

Synonyms

galactarate dehydratase (D-threo-forming), GalrD-II

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.158 galactarate dehydratase (D-threo-forming)

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Results	in table
2	AA Sequence
1	Crystallization (Commentary)
1	kcat/KM [mM/s]
1	KM Value [mM]
1	Metals/Ions
2	Organism
2	Protein Variants
1	Reaction
2	Reference
2	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.1.158 - galactarate dehydratase (D-threo-forming)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

galactarate

2-oxo-D-threo-4,5-dihydroxyadipate + H2O

2 entries

galactarate

2-oxo-D-threo-4,5-dihydroxyadipate + H2O

Oceanobacillus iheyensis

Q8EMJ9

-

702265

i.e. (2S,3R)-2,3-dihydroxy-5-oxohexanedioate. Product is the enantiomer of the product obtained in the reaction catalyzed by bifunctional L-talarate/galactarate dehydratase. When the GalrD-II-catalyzed reaction is performed in D2O, the proS hydrogen is replaced with deuterium, i.e., the acid that facilitates the departure of the OH group is likely the acid that catalyzes the formation of the alpha-oxo-beta-methylene product

-

?

galactarate

2-oxo-D-threo-4,5-dihydroxyadipate + H2O

Oceanobacillus iheyensis DSM 14371

Q8EMJ9

-

702265

i.e. (2S,3R)-2,3-dihydroxy-5-oxohexanedioate. Product is the enantiomer of the product obtained in the reaction catalyzed by bifunctional L-talarate/galactarate dehydratase. When the GalrD-II-catalyzed reaction is performed in D2O, the proS hydrogen is replaced with deuterium, i.e., the acid that facilitates the departure of the OH group is likely the acid that catalyzes the formation of the alpha-oxo-beta-methylene product

-

?