4.2.1.152: hydroperoxy icosatetraenoate dehydratase

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For detailed information about hydroperoxy icosatetraenoate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.152

4.2.1.152

alox12b

ichthyosiform

erythroderma

lamellar

nipal4

abca12

cyp4f22

12r-lox

pnpla1

harlequin

12r-lipoxygenase

ichthyoses

hepoxilins

collodion

lipoxygenase-3

sdr9c7

cornification

non-bullous

galicia

self-healing

corneocyte

self-improving

Reaction

Synonyms

ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, epidermis-type lipoxygenase 3, hepoxilin synthase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.152 hydroperoxy icosatetraenoate dehydratase

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638	AA Sequence
5	Cloned(Commentary)
125	Disease/ Diagnostics
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1	Inhibitors
14	Natural Substrates/ Products (Substrates)
8	Organism
2	Pathway
8	PDB ID
3	Protein Variants
4	Purification (Commentary)
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7	Source Tissue
22	Substrates and Products (Substrate)
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1	Systematic Name

Systematic Name

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Systematic Name on EC 4.2.1.152 - hydroperoxy icosatetraenoate dehydratase

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hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)

Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.