4.2.1.152: hydroperoxy icosatetraenoate dehydratase

This is an abbreviated version!
For detailed information about hydroperoxy icosatetraenoate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.152

4.2.1.152

alox12b

ichthyosiform

erythroderma

lamellar

nipal4

abca12

cyp4f22

12r-lox

pnpla1

harlequin

12r-lipoxygenase

ichthyoses

hepoxilins

collodion

lipoxygenase-3

sdr9c7

cornification

non-bullous

galicia

self-healing

corneocyte

self-improving

Reaction

Synonyms

ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, epidermis-type lipoxygenase 3, hepoxilin synthase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.152 hydroperoxy icosatetraenoate dehydratase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	Activating Compound
638	AA Sequence
5	Cloned(Commentary)
125	Disease/ Diagnostics
4	General Information
1	Inhibitors
14	Natural Substrates/ Products (Substrates)
8	Organism
2	Pathway
8	PDB ID
3	Protein Variants
4	Purification (Commentary)
1	Reaction
8	Reference
7	Source Tissue
22	Substrates and Products (Substrate)
20	Synonyms
1	Systematic Name

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 4.2.1.152 - hydroperoxy icosatetraenoate dehydratase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Substrate/Product Search

(12R)-HPETE

(8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O

Homo sapiens

preferred substrate

729275

(12R)-HPETE

2 entries

(12R)-hydroperoxyeicosatetraenoic acid

(8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid

Homo sapiens

preferred substrate

648497

2:1 ratio, 2:1 product ratio

(12S)-HPETE

2 entries

(12S)-hydroperoxyeicosatetraenoic acid

(10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid

Homo sapiens

648497

(15S)-HPETE

(15S)HETE + H2O

Homo sapiens

729275

(15S)-HPETE

2 entries

(15S)-hydroperoxyeicosatetraenoic acid

(13R)-hydroxy-(14S,15S)-epoxyeicosa-(5Z,8Z,11Z)-trienoic acid + 12-oxoeicosatetraenoic acid

Homo sapiens

648497

(5S)-HPETE

(7R)-hydroxy-(5S,6S)-epoxyeicosa-(8Z,11Z,14Z)-trienoic acid + H2O

2 entries

(5Z,8Z,10E,12R,14Z)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate

(8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoate + H2O

Homo sapiens

730305

(8R)-HPETE

2 entries

(8S)-HPETE

(10R)-hydroxy-(8S,9S)-epoxyeicosa-(5Z,11Z,14Z)-trienoic acid + H2O

Mus musculus

729096

(9E,11Z,14Z)-20:3omega6

(9S)-hydroperoxy-(10E,12E,14Z)-eicosatrienoic acid + H2O

Homo sapiens

good substrate

729971

arachidonic acid + O2

5-HPETE + 7-HPETE + 9-HPETE

Homo sapiens

in the absence of fatty acid hydroperoxides, the enzyme shows only weak and slow activity with arachidonic acid

729971

22%, 25%, and 29% yield, respectively

arachidonoyl-lysophosphatidic acid

15-HPETE-lysophosphatidic acid + 13-HPETE-lysophosphatidic acid + 11HPETE-lysophosphatidic acid + 5-HPETE-lysophosphatidic acid + H2O

Homo sapiens

729971

36%, 22%, 21%, and 13% yield, respectively

additional information

Homo sapiens

linoleic, arachidonic, and eicosapentaenoic acids, the methyl esters of arachidonic acid and linoleic acid, arachidonyl phosphatidylcholine, anandamide, and the cholesteryl ester of arachidonic acid are no substrates

648497