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4.2.1.152: hydroperoxy icosatetraenoate dehydratase

This is an abbreviated version!
For detailed information about hydroperoxy icosatetraenoate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.152

Reaction

a hydroperoxyicosatetraenoate
=
an oxoicosatetraenoate
 +
H2O

Synonyms

ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, epidermis-type lipoxygenase 3, hepoxilin synthase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.152 hydroperoxy icosatetraenoate dehydratase

General Information

General Information on EC 4.2.1.152 - hydroperoxy icosatetraenoate dehydratase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the lipoxygenase (LOX) family contains enzymes catalyzing dioxygenation or, for epidermis-type lipoxygenase 3 (eLOX-3), hydroperoxide isomerization of polyunsaturated fatty acids. Five LOX mRNAs are known to be expressed in human epidermal cells: eLOX-3, 12R-lipoxygenase (12RLOX), 12S-lipoxygenase (12S-LOX), 15-lipoxygenase 1 (15-LOX-1), and 15-lipoxygenase 2 (15-LOX-2), expression profiles, overview
malfunction
mutations in nine different genes are known to be responsible for ichthyoses. One of them is the lipoxygenase gene Aloxe3 encoding the epidermal lipoxygenase-3 (eLOX-3). eLOX-3-deficient mice decease rapidly after birth due to transepidermal water loss, short life-span of eLOX-3 null mice. For a prenatal gene therapy approach, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, is undertaken resulting in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicate a lack of glycogen trophoblasts in the junctional zone, overview. Placenta-specific gene expression is altered. Thus, the observed prenatal toxicity of eLOX-3 can be due to a strong effect on placental development
physiological function