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4.2.1.152: hydroperoxy icosatetraenoate dehydratase

This is an abbreviated version!
For detailed information about hydroperoxy icosatetraenoate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.152

Reaction

a hydroperoxyicosatetraenoate
=
an oxoicosatetraenoate
+
H2O

Synonyms

ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, epidermis-type lipoxygenase 3, hepoxilin synthase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.152 hydroperoxy icosatetraenoate dehydratase

Engineering

Engineering on EC 4.2.1.152 - hydroperoxy icosatetraenoate dehydratase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A451G
-
unlike wild type enzyme, the mutant reacts well with arachidonic acid even in the absence of fatty acid hydroperoxides, yet only after an unusually long lag phase of about 20 min
R396S
-
inactive
V500F
-
inactive