4.2.1.150: short-chain-enoyl-CoA hydratase

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For detailed information about short-chain-enoyl-CoA hydratase, go to the full flat file.

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Synonyms

3-hydroxyacyl-CoA dehydratase, 3-hydroxybutyryl-CoA dehydratase, CaCRT, CDYL, chromodomain Y-like protein, crotonase, crotonyl-CoA hydratase, crt, L-3-hydroxyacyl-CoA hydro-lyase, More, Mr-Crt, Mrub_2284, Msed_0399

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.150 short-chain-enoyl-CoA hydratase

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Results	in table
1124	AA Sequence
5	Cloned(Commentary)
1	Crystallization (Commentary)
6	Disease/ Diagnostics
22	General Information
1	General Stability
4	Inhibitors
2	kcat/KM [mM/s]
8	KM Value [mM]
3	Localization
8	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
18	Organism
17	Pathway
3	PDB ID
5	pH Optimum
1	pH Range
8	Protein Variants
6	Purification (Commentary)
3	Reaction
16	Reference
8	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
25	Substrates and Products (Substrate)
12	Subunits
38	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.1.150 - short-chain-enoyl-CoA hydratase

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short-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase

The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. It is specific for short, C4-C6, chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. cf. EC 4.2.1.17, enoyl-CoA hydratase and EC 4.2.1.74, long-chain-enoyl-CoA hydratase.