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4.2.1.129: squalene-hopanol cyclase

This is an abbreviated version!
For detailed information about squalene-hopanol cyclase, go to the full flat file.

Reaction

hopan-22-ol
=
squalene
+
H2O

Synonyms

SHC, squalene-hopene cyclase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.129 squalene-hopanol cyclase

Localization

Localization on EC 4.2.1.129 - squalene-hopanol cyclase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SHC in vivo is a membrane-associated protein and can be solubilized from cell extracts by nonionic detergents, such as Triton X-100 or octylthioglucopyranoside. The enzyme is attached to the inner side of the cytoplasmic membrane by interactions of hydrophobic residues with the phospholipids. The membrane-binding part of the enzyme is a nonpolar region that is encircled by positive-charged amino acids enforcing the anchoring of the enzyme to the negatively charged surface of the phospholipid membrane
Manually annotated by BRENDA team