4.2.1.129: squalene-hopanol cyclase
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For detailed information about squalene-hopanol cyclase, go to the full flat file.
Reaction
Synonyms
SHC, squalene-hopene cyclase
ECTree
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Localization
Localization on EC 4.2.1.129 - squalene-hopanol cyclase
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SHC in vivo is a membrane-associated protein and can be solubilized from cell extracts by nonionic detergents, such as Triton X-100 or octylthioglucopyranoside. The enzyme is attached to the inner side of the cytoplasmic membrane by interactions of hydrophobic residues with the phospholipids. The membrane-binding part of the enzyme is a nonpolar region that is encircled by positive-charged amino acids enforcing the anchoring of the enzyme to the negatively charged surface of the phospholipid membrane