4.2.1.122: tryptophan synthase (indole-salvaging)

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For detailed information about tryptophan synthase (indole-salvaging), go to the full flat file.

Reaction

Synonyms

PfTrpB, PfTrpS, StTrpS (beta2), Trp synthase, TrpB2, TrpBbeta, TRPS, tryptophan synthase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.122 tryptophan synthase (indole-salvaging)

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Results	in table
30	AA Sequence
1	Application
7	Cloned(Commentary)
1	Cofactor
2	Expression
11	General Information
13	kcat/KM [mM/s]
15	KM Value [mM]
5	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
9	Organism
1	Pathway
3	pH Optimum
1	pI Value
13	Protein Variants
3	Purification (Commentary)
3	Reaction
9	Reference
37	Substrates and Products (Substrate)
6	Subunits
11	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
12	Turnover Number [1/s]

Reference

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Reference on EC 4.2.1.122 - tryptophan synthase (indole-salvaging)

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652353

Hettwer, S.; Sterner, R.

A novel tryptophan synthase beta-subunit from the hyperthermophile Thermotoga maritima. Quaternary structure, steady-state kinetics, and putative physiological role

J. Biol. Chem.

277

8194-8201

2002

Thermotoga maritima

11756459

727489

Hiyama, T.; Sato, T.; Imanaka, T.; Atomi, H.

The tryptophan synthase beta-subunit paralogs TrpB1 and TrpB2 in Thermococcus kodakarensis are both involved in tryptophan biosynthesis and indole salvage

FEBS J.

281

3113-3125

2014

Thermococcus kodakarensis (Q5JDJ1), Thermococcus kodakarensis (Q9YGB0)

24835339

747116

Buller, A.; Van Roye, P.; Murciano-Calles, J.; Arnold, F.

tryptophan synthase uses an atypical mechanism to achieve substrate specificity

Biochemistry

7043-7046

2016

Pyrococcus furiosus

27935677

747549

Francis, D.; Winn, M.; Latham, J.; Greaney, M.; Micklefield, J.

An engineered tryptophan synthase opens new enzymatic pathways to beta-methyltryptophan and derivatives

ChemBioChem

382-386

2017

Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 37845

28005309

747575

Blei, F.; Baldeweg, F.; Fricke, J.; Hoffmeister, D.

Biocatalytic production of psilocybin and derivatives in tryptophan synthase-enhanced reactions

Chemistry

10028-10031

2018

Psilocybe cubensis (A0A2U8JPY3)

29750381

747735

Hiyama, T.; Sato, T.; Imanaka, T.; Atomi, H.

The tryptophan synthase beta-subunit paralogs TrpB1 and TrpB2 in Thermococcus kodakarensis are both involved in tryptophan biosynthesis and indole salvage

FEBS J.

281

3113-3125

2014

Thermococcus kodakarensis

24835339

748036

Herger, M.; Van Roye, P.; Romney, D.; Brinkmann-Chen, S.; Buller, A.; Arnold, F.

Synthesis of beta-branched tryptophan analogues using an engineered subunit of tryptophan synthase

J. Am. Chem. Soc.

138

8388-8391

2016

Pyrococcus furiosus

27355405