4.2.1.117: 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
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Reaction
Synonyms
AcnD, SO_0343
ECTree
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Systematic Name
Systematic Name on EC 4.2.1.117 - 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
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(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate forming)
Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein.