4.2.1.115: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
This is an abbreviated version!
For detailed information about UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting), go to the full flat file.
Word Map on EC 4.2.1.115
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4.2.1.115
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flagellins
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spirochete
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pylori
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flagella
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helicobacter
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jejuni
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campylobacter
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hyodysenteriae
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pseudaminic
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serpulina
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flab
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sheath
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interrogans
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hexameric
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dysentery
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o-antigen
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non-motile
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leptospiral
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enteropathogenicity
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pilosicoli
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innocens
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udp-n-acetyl-d-glucosamine
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brachyspira
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ecorv
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bacillosamine
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syk
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drug development
- 4.2.1.115
- flagellins
-
spirochete
- pylori
-
flagella
- helicobacter
- jejuni
- campylobacter
- hyodysenteriae
-
pseudaminic
- serpulina
-
flab
-
sheath
- interrogans
-
hexameric
- dysentery
-
o-antigen
-
non-motile
-
leptospiral
-
enteropathogenicity
- pilosicoli
- innocens
- udp-n-acetyl-d-glucosamine
- brachyspira
- ecorv
-
bacillosamine
- syk
- drug development
Reaction
Synonyms
4,6-dehydratase/5-epimerase, CapE, Cj1293, FlaA1, HP0840, inverting 4,6-dehydratase, Mg534, More, NAD(P)+-dependent dehydratase/epimerase, PseB, UDP-alpha-D-GlcNAc modifying dehydratase, UDP-GlcNAc 5-inverting 4,6-dehydratase, UDP-GlcNAc C6 dehydratase, UDP-GlcNAc C6 dehydratase/C4 reductase, UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase, WbpM
ECTree
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Reaction
Reaction on EC 4.2.1.115 - UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
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UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
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UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
reaction mechanism
UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
Asp126, Lys127, and Tyr135 are the active site residues
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UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
reaction mechanism of WbpM
UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
reaction mechanism, FlaA1 is a UDP-GlcNAc 4,6-dehydratase that additionally inverts the chirality at the C-5 position
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UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
catalytic mechanism of CapE, overview. Tyr164 does not act as the general base as it does in SDR enzymes displaying the SYK triad motif