4.2.1.112: acetylene hydratase

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For detailed information about acetylene hydratase, go to the full flat file.

Reaction

Synonyms

(E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, AH, HMBPP reductase, ispH, More, tungsten-dependent acetylene hydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.112 acetylene hydratase

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Results	in table
8	Activating Compound
146	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
22	Cofactor
6	Crystallization (Commentary)
13	General Information
15	Inhibitors
5	KM Value [mM]
4	Localization
49	Metals/Ions
6	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
33	Organism
2	Oxidation Stability
3	Pathway
4	pH Optimum
1	pH Range
1	pI Value
18	Protein Variants
3	Purification (Commentary)
15	Reaction
27	Reference
17	Source Tissue
9	Specific Activity [micromol/min/mg]
1	Storage Stability
45	Substrates and Products (Substrate)
12	Subunits
7	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]

Systematic Name

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Systematic Name on EC 4.2.1.112 - acetylene hydratase

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SYSTEMATIC NAME

IUBMB Comments

acetaldehyde hydro-lyase (acetylene-forming)

This is a non-redox-active enzyme that contains two molybdopterin guanine dinucleotide (MGD) cofactors, a tungsten centre and a cubane type [4Fe-4S] cluster [2].The tungsten centre binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket [2]. Ethylene cannot act as a substrate [1].