4.2.1.112: acetylene hydratase
This is an abbreviated version!
For detailed information about acetylene hydratase, go to the full flat file.
Word Map on EC 4.2.1.112
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4.2.1.112
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pelobacter
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acetylenicus
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tungstoenzyme
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wiv
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nonredox
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bioinspired
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w-containing
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e-4-hydroxy-3-methyl-but-2-enyl
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qm-only
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pterin
- 4.2.1.112
- pelobacter
- acetylenicus
-
tungstoenzyme
- wiv
-
nonredox
-
bioinspired
-
w-containing
-
e-4-hydroxy-3-methyl-but-2-enyl
-
qm-only
- pterin
Reaction
Synonyms
(E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, AH, HMBPP reductase, ispH, More, tungsten-dependent acetylene hydratase
ECTree
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Substrates Products
Substrates Products on EC 4.2.1.112 - acetylene hydratase
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REACTION DIAGRAM
but-3-ynyl diphosphate
4-oxobutyl diphosphate
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via (E)-4-hydroxybut-3-enyl diphosphate
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?
acetylene + H2O
acetaldehyde
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?
acetylene + H2O
acetaldehyde
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the subsequent disproportionation of acetaldehyde yields acetate and ethanol
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?
acetylene + H2O
acetaldehyde
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the hydration reaction is unique for a tungsten and molybdenum containing enzyme, which are usually redox enzymes
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r
acetylene + H2O
acetaldehyde
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the active site residues Asp13, Lys48, and Ile142 are involved in catalysis. Asp13 close to W(IV) coordinates two molybdopterin-guanosine-dinucleotide ligands, Lys48 couples the [4Fe-4S] cluster to the W site, and Ile142 is part of a hydrophobic ring at the end of the substrate access channel designed to accommodate the substrate acetylene
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r
acetylene + H2O
acetaldehyde
Syntrophotalea acetylenica WoAcy1 / DSM 3246
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the subsequent disproportionation of acetaldehyde yields acetate and ethanol
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?
acetylene + H2O
acetaldehyde
Syntrophotalea acetylenica WoAcy1 / DSM 3246
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the active site residues Asp13, Lys48, and Ile142 are involved in catalysis. Asp13 close to W(IV) coordinates two molybdopterin-guanosine-dinucleotide ligands, Lys48 couples the [4Fe-4S] cluster to the W site, and Ile142 is part of a hydrophobic ring at the end of the substrate access channel designed to accommodate the substrate acetylene
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r
?
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the enzyme is highly specific for acetylene
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?
additional information
?
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Norcadia rhodochorous
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the enzyme is highly specific for acetylene
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?
additional information
?
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the enzyme is highly specific for acetylene
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?
additional information
?
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the enzyme is highly specific for acetylene
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?
additional information
?
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the enzyme is highly specific for acetylene
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?
additional information
?
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the enzyme is highly specific for acetylene
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?
additional information
?
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no activity with ethylene, methylene blue, or anthraquinone disulfonate, the purified enzyme has no coenzyme A-acetylating aldehyde dehydrogenase activity
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?
additional information
?
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no activity with propyne, ethylene, and acetonitrile, calculated barriers for hydration of the compounds compared to acetylene, overview
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?
additional information
?
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the enzyme is highly specific for acetylene
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?
additional information
?
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the enzyme is highly specific for acetylene
-
-
?
additional information
?
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Syntrophotalea acetylenica WoAcy1 / DSM 3246
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no activity with ethylene, methylene blue, or anthraquinone disulfonate, the purified enzyme has no coenzyme A-acetylating aldehyde dehydrogenase activity
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-
?