4.2.1.111: 1,5-anhydro-D-fructose dehydratase

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For detailed information about 1,5-anhydro-D-fructose dehydratase, go to the full flat file.

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Synonyms

1,5-anhydro-D-arabino-hex-2-ulose dehydratase, 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydro-lyase, 1,5-anhydro-D-fructose hydrolyase, AF dehydratase, AFDH

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.111 1,5-anhydro-D-fructose dehydratase

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Results	in table
1	CAS Registry Number
2	Inhibitors
6	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
8	Organism
1	Pathway
2	pH Optimum
2	pH Range
1	Purification (Commentary)
1	Reaction
8	Reference
1	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
3	Subunits
21	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 4.2.1.111 - 1,5-anhydro-D-fructose dehydratase

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SYSTEMATIC NAME

IUBMB Comments

1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming)

This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase] and EC 5.3.2.7 (ascopyrone tautomerase). Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity. Unlike EC 4.2.1.110, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity towards aldose-2-uloses such as 2-dehydroglucose [1,2,3]. In addition, it is inhibited by its end-product ascopyrone M [2] and it cannot convert ascopyrone M into microthecin, as can EC 4.2.1.110.