4.2.1.110: aldos-2-ulose dehydratase
This is an abbreviated version!
For detailed information about aldos-2-ulose dehydratase, go to the full flat file.
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Synonyms
1,5-anhydro-D-fructose dehydratase (microthecin-forming), aldos-2-ulose dehydratase, aldos-2-ulose dehydratase/isomerase, aldosulose-utilizing enzyme, AUDH, pyranosone dehydratase
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General Information
General Information on EC 4.2.1.110 - aldos-2-ulose dehydratase
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malfunction
removal of two zinc ions at the bottom of two putative active-site clefts in the propeller and the cupin domains leads to loss of enzymatic activity, although the structure of the Zn2+-depleted enzyme is very similar to that of native AUDH
physiological function
the bifunctional enzyme aldos-2-ulose dehydratase/isomerase participates in carbohydrate secondary metabolism, catalyzing the conversion of glucosone and 1,5-D-anhydrofructose to the secondary metabolites cortalcerone and microthecin, respectively