4.2.1.109: methylthioribulose 1-phosphate dehydratase
This is an abbreviated version!
For detailed information about methylthioribulose 1-phosphate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.109
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4.2.1.109
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salvage
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caspase-9
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dioxygenase
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5-methylthioadenosine
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aci-reductone
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enolization
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tetrahymena
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etoposide
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pyroptosis
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apoptosome
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thermophila
- 4.2.1.109
-
salvage
- caspase-9
- dioxygenase
- 5-methylthioadenosine
-
aci-reductone
-
enolization
- tetrahymena
- etoposide
-
pyroptosis
- apoptosome
- thermophila
Reaction
Synonyms
1-PMT-ribulose dehydratase, 5'-methylthioribulose-1-phosphate dehydratase, 5-Methylthioribulose-1-phosphate, 5-methylthioribulose-1-phosphate dehydratase, 5’-methylthioribulose-1-phosphate dehydratase, Apaf-1 interacting protein, Apaf-1-interacting protein, APIP, Mde1p, MtnB, MtnBD, MTRu-1-P dehydratase, MTRu-1-P dehydratase/enolase
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Metals Ions
Metals Ions on EC 4.2.1.109 - methylthioribulose 1-phosphate dehydratase
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Zn2+
additional information
near the zinc ion, the surface of the active site pocket is formed by several residues, including Cys97, Tyr198, Glu139, Lys142, and Asn166. Residues Cys97, Glu139, and Tyr198 form hydrogen bonds with the three water molecules that coordinate the zinc ion
MtnB requires metal ions for catalysis, but it is unclear what kind of metal ions are bound to the MtnB purified from Escherichia coli cells. Considering that FucA/RibE/RhuA-related enzymes require the zinc ion for optimal catalysis under physiological conditions and that recombinant class II aldolase enzymes expressed in Escherichia coli cells are almost all of the Zn2+ form, purified MtnB might also be of the Zn2+ form
additional information
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MtnB requires metal ions for catalysis, but it is unclear what kind of metal ions are bound to the MtnB purified from Escherichia coli cells. Considering that FucA/RibE/RhuA-related enzymes require the zinc ion for optimal catalysis under physiological conditions and that recombinant class II aldolase enzymes expressed in Escherichia coli cells are almost all of the Zn2+ form, purified MtnB might also be of the Zn2+ form