4.2.1.109: methylthioribulose 1-phosphate dehydratase

This is an abbreviated version!
For detailed information about methylthioribulose 1-phosphate dehydratase, go to the full flat file.

Reaction

Synonyms

1-PMT-ribulose dehydratase, 5'-methylthioribulose-1-phosphate dehydratase, 5-Methylthioribulose-1-phosphate, 5-methylthioribulose-1-phosphate dehydratase, 5�-methylthioribulose-1-phosphate dehydratase, Apaf-1 interacting protein, Apaf-1-interacting protein, APIP, Mde1p, MtnB, MtnBD, MTRu-1-P dehydratase, MTRu-1-P dehydratase/enolase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.109 methylthioribulose 1-phosphate dehydratase

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Results	in table
7813	AA Sequence
3	Cloned(Commentary)
1	Crystallization (Commentary)
16	Disease/ Diagnostics
10	General Information
1	KM Value [mM]
2	Localization
3	Metals/Ions
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
4	PDB ID
3	pH Optimum
1	pH Range
7	Protein Variants
3	Purification (Commentary)
2	Reaction
2	Reaction Type
10	Reference
2	Source Tissue
12	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Turnover Number [1/s]

Engineering

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Engineering on EC 4.2.1.109 - methylthioribulose 1-phosphate dehydratase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D72A

Homo sapiens

Q96GX9

site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme

730835

D72A/K90A

Homo sapiens

Q96GX9

site-directed mutagenesis, the mutant shows a similar level of pyroptosis inhibition as the wild-type enzyme, but a significant loss of apoptosis inhibition activity

730835

K90A

Homo sapiens

Q96GX9

site-directed mutagenesis, the mutant shows a similar level of pyroptosis inhibition as the wild-type enzyme, but a significant loss of apoptosis inhibition activity

730835

P185A

Homo sapiens

Q96GX9

site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme

730835

Y184A

Homo sapiens

Q96GX9

site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme

730835

Y184A/P185A

Homo sapiens

Q96GX9

site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme

730835

additional information

2 entries

additional information

Homo sapiens

Q96GX9

transient silencing of the enzyme in HeLa cells. Stable knockdown of the enzyme specifically affects growth in 5-methylthioadenosine and depletes intracellular levels of methionine

728588

additional information

Homo sapiens

-

transient silencing of the enzyme in HeLa cells. Stable knockdown of the enzyme specifically affects growth in 5-methylthioadenosine and depletes intracellular levels of methionine

728588